Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 우소연 | * |
dc.contributor.author | 조경아 | * |
dc.contributor.author | 김유희 | * |
dc.date.accessioned | 2021-11-09T16:31:03Z | - |
dc.date.available | 2021-11-09T16:31:03Z | - |
dc.date.issued | 2021 | * |
dc.identifier.issn | 1013-9087 | * |
dc.identifier.issn | 2005-3894 | * |
dc.identifier.other | OAK-30259 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/259221 | - |
dc.description.abstract | Background: Mast cells are skin immune sentinels located in the upper dermis, where wheal formation and sensory nerve stimulation take place. Skin inflammation is occasionally accompanied by mast cell-driven responses with wheals, angioedema, or both. Immunoglobulin E (IgE) antibodies are regarded as typical stimuli to drive mast cell activation. However, various causative factors, including microbial infections, can drive IgE-independent mast cell response. When infected, the innate immunity orchestrates an immune response by activating receptor signaling via Toll-like receptors (TLRs). Objective: In this study, we determined the effect of TLR7 stimulation on mast cells to investigate the possible mechanism of IgE-independent inflammatory response. Methods: Human mast cell (HMC) line, HMC-1 cells were treated with TLR7 agonist and the morphologic alteration was observed in transmission electron microscopy. Further, TLR7 agonist treated HMC-1 cells were conducted to RNA sequencing to compare transcriptomic features. Results: HMC-1 cells treated with TLR7 agonist reveals increase of intracellular vesicles, lipid droplets, and ribosomes. Also, genes involved in pro-inflammatory responses such as angiogenesis are highly expressed, and Il12rb2 was the most highly up regulated gene. Conclusion: Our data suggest that TLR7 signaling on mast cells might be a potential therapeutic target for mast cell-driven, IgE-independent skin inflammation. (Ann Dermatol 33(5) 402 similar to 408, 2021) | * |
dc.language | English | * |
dc.publisher | KOREAN DERMATOLOGICAL ASSOC | * |
dc.subject | Mast cell | * |
dc.subject | Skin inflammation | * |
dc.subject | Toll-like receptor 7 | * |
dc.title | Toll-Like Receptor 7 (TLR7) Mediated Transcriptomic Changes on Human Mast Cells | * |
dc.type | Article | * |
dc.relation.issue | 5 | * |
dc.relation.volume | 33 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 402 | * |
dc.relation.lastpage | 408 | * |
dc.relation.journaltitle | ANNALS OF DERMATOLOGY | * |
dc.identifier.doi | 10.5021/ad.2021.33.5.402 | * |
dc.identifier.wosid | WOS:000704343600002 | * |
dc.identifier.scopusid | 2-s2.0-85116756651 | * |
dc.author.google | Cho, Kyung-Ah | * |
dc.author.google | Choi, Da-Won | * |
dc.author.google | Park, Minhwa | * |
dc.author.google | Kim, Yu-Hee | * |
dc.author.google | Woo, So-Youn | * |
dc.contributor.scopusid | 우소연(7402853365) | * |
dc.contributor.scopusid | 조경아(21734204400) | * |
dc.contributor.scopusid | 김유희(15764983100) | * |
dc.date.modifydate | 20240311140754 | * |