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Sulfur-based fluorescent probes for HOCl: Mechanisms, design, and applications

Title
Sulfur-based fluorescent probes for HOCl: Mechanisms, design, and applications
Authors
Hou J.-T.Kwon N.Wang S.Wang B.He X.Yoon J.Shen J.
Ewha Authors
윤주영
SCOPUS Author ID
윤주영scopus
Issue Date
2022
Journal Title
Coordination Chemistry Reviews
ISSN
0010-8545JCR Link
Citation
Coordination Chemistry Reviews vol. 450
Keywords
BioimagingHypochlorous acid/hypochloriteReaction mechanismReactive oxygen speciesSulfur-based fluorescent sensors
Publisher
Elsevier B.V.
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Review
Abstract
Hypochlorous acid (HOCl) is an endogenously produced reactive oxygen species (ROS), which acts as a protector against microbes. However, its aberrant production is implicated in various oxidative-stress related pathophysiological processes, such as cardiovascular disorders, arthritis, and neurodegenerative diseases. Therefore, the direct, rapid, sensitive, and selective detection of endogenous HOCl in living systems is of essential importance for better understanding the HOCl-involved chemical biology. In the last two decades, sulfur-based fluorescent probes for HOCl have been widely designed and they usually show rapid reaction rate, high selectivity and excellent sensitivity. This review summarized the advances that have been made in the development of sulfur-based fluorescent probes for HOCl, and their reaction mechanisms were emphatically discussed. Lastly, the achievements, challenges, and perspectives in this field were outlooked. © 2021 Elsevier B.V.
DOI
10.1016/j.ccr.2021.214232
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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