View : 51 Download: 0

Full metadata record

DC Field Value Language
dc.contributor.author권영주-
dc.contributor.author전경화-
dc.date.accessioned2021-11-09T16:30:05Z-
dc.date.available2021-11-09T16:30:05Z-
dc.date.issued2022-
dc.identifier.issn0223-5234-
dc.identifier.otherOAK-30323-
dc.identifier.uriD:/dspace/dspace55/handle/2015.oak/259164-
dc.description.abstractBased on previous reports on the significance of halogen moieties and the indenopyridin-5-one skeleton, we designed and synthesized a novel series of halogen (F−, Cl−, Br−, CF3− and OCF3−)-containing 2,4-diphenyl indenopyridin-5-ones and their corresponding -5-ols. Unlike indenopyridin-5-ols, most of the prepared indenopyridin-5-ones with Cl−, Br−, and CF3− groups at the 2-phenyl ring conferred a strong dual topoisomerase I/IIα inhibitory effect. Among the series, para-bromophenyl substituted compound 9 exhibited the most potent topoisomerase inhibition and antiproliferative effects, which showed dependency upon the topoisomerase gene expression level of diverse cancer cells. In particular, as a DNA minor groove-binding non-intercalative topoisomerase I/IIα catalytic inhibitor, compound 9 synergistically promoted the anticancer efficacy of clinically applied topoisomerase I/IIα poisons both in vitro and in vivo, having the great advantage of alleviating poison-related toxicities. © 2021 Elsevier Masson SAS-
dc.languageEnglish-
dc.publisherElsevier Masson s.r.l.-
dc.titleIdentification of new halogen-containing 2,4-diphenyl indenopyridin-5-one derivative as a boosting agent for the anticancer responses of clinically available topoisomerase inhibitors-
dc.typeArticle-
dc.relation.volume227-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.journaltitleEuropean Journal of Medicinal Chemistry-
dc.identifier.doi10.1016/j.ejmech.2021.113916-
dc.identifier.wosidWOS:000708741900015-
dc.identifier.scopusid2-s2.0-85117227246-
dc.author.googleHwang S.-Y.-
dc.author.googleShrestha A.-
dc.author.googlePark S.-
dc.author.googleBist G.-
dc.author.googleKunwar S.-
dc.author.googleKadayat T.M.-
dc.author.googleJang H.-
dc.author.googleSeo M.-
dc.author.googleSheen N.-
dc.author.googleKim S.-
dc.author.googleJeon K.-H.-
dc.author.googleLee E.-S.-
dc.author.googleKwon Y.-
dc.contributor.scopusid권영주(12446435600;57281846700)-
dc.contributor.scopusid전경화(42061515400)-
dc.date.modifydate20220119154509-
Appears in Collections:
약학대학 > 약학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE