Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김희선 | * |
dc.contributor.author | 박진선 | * |
dc.date.accessioned | 2021-11-09T16:30:04Z | - |
dc.date.available | 2021-11-09T16:30:04Z | - |
dc.date.issued | 2021 | * |
dc.identifier.issn | 1976-9148 | * |
dc.identifier.issn | 2005-4483 | * |
dc.identifier.other | OAK-30333 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/259156 | - |
dc.description.abstract | Parkinson's disease (PD) is a neurodegenerative disorder that involves the loss of dopaminergic neurons in the substantia nigra (SN). Matrix metalloproteinases-8 (MMP-8), neutrophil collagenase, is a functional player in the progressive pathology of various inflammatory disorders. In this study, we administered an MMP-8 inhibitor (MMP-8i) in Leucine-rich repeat kinase 2 (LRRK2) G2019S transgenic mice, to determine the effects of MMP-8i on PD pathology. We observed a significant increase of ionized calcium-binding adapter molecule 1 (Iba1)-positive activated microglia in the striatum of LRRK2 G2019S mice compared to normal control mice, indicating enhanced neuro-inflammatory responses. The increased number of Iba1-positive activated microglia in LRRK2 G2019S PD mice was down-regulated by systemic administration of MMP-8i. Interestingly, this LRRK2 G2019S PD mice showed significantly reduced size of cell body area of tyrosine hydroxylase (TH) positive neurons in SN region and MMP-8i significantly recovered cellular atrophy shown in PD model indicating distinct neuro-protective effects of MMP-8i. Furthermore, MMP-8i administration markedly improved behavioral abnormalities of motor balancing coordination in rota-rod test in LRRK2 G2019S mice. These data suggest that MMP-8i attenuates the pathological symptoms of PD through anti-inflammatory processes. | * |
dc.language | English | * |
dc.publisher | KOREAN SOC APPLIED PHARMACOLOGY | * |
dc.subject | Parkinson's disease (PD) | * |
dc.subject | Matrix metalloproteinase-8 (MMP-8) | * |
dc.subject | Neuro-inflammation | * |
dc.subject | Neuroprotection | * |
dc.title | Matrix Metalloproteinase-8 Inhibitor Ameliorates Inflammatory Responses and Behavioral Deficits in LRRK2 G2019S Parkinson's Disease Model Mice | * |
dc.type | Article | * |
dc.relation.issue | 5 | * |
dc.relation.volume | 29 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 483 | * |
dc.relation.lastpage | 491 | * |
dc.relation.journaltitle | BIOMOLECULES & THERAPEUTICS | * |
dc.identifier.doi | 10.4062/biomolther.2020.181 | * |
dc.identifier.wosid | WOS:000710686000003 | * |
dc.author.google | Kim, Taewoo | * |
dc.author.google | Jeon, Jeha | * |
dc.author.google | Park, Jin-Sun | * |
dc.author.google | Park, Yeongwon | * |
dc.author.google | Kim, Jooeui | * |
dc.author.google | Noh, Haneul | * |
dc.author.google | Kim, Hee-Sun | * |
dc.author.google | Seo, Hyemyung | * |
dc.contributor.scopusid | 김희선(57191372551) | * |
dc.contributor.scopusid | 박진선(54914743600) | * |
dc.date.modifydate | 20240215165648 | * |