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Lactoferrin: Potential functions, pharmacological insights, and therapeutic promises

Title
Lactoferrin: Potential functions, pharmacological insights, and therapeutic promises
Authors
Ahmed K.A.Saikat A.S.M.Moni A.Kakon S.A.M.Islam M.R.Uddin M.J.
Ewha Authors
Md Jamal Uddin
SCOPUS Author ID
Md Jamal Uddinscopus
Issue Date
2021
Journal Title
Journal of Advanced Biotechnology and Experimental Therapeutics
ISSN
2616-4760JCR Link
Citation
Journal of Advanced Biotechnology and Experimental Therapeutics vol. 4, no. 2, pp. 223 - 237
Keywords
FunctionsLactoferrinPathophysiology. therapeutic promisesProtective effects
Publisher
Bangladesh Society for Microbiology, Immunology and Advanced Biotechnology
Indexed
SCOPUS scopus
Document Type
Review
Abstract
Lactoferrin (LF) is an iron-binding multifunctional glycoprotein, act as a natural protective agent. In general, LF is involved in various physiological activities, including antibacterial, antifungal, antiviral, antiparasitic, anticarcinogenic and iron metabolism. The LF is most frequently found in milk as well as many other exocrine secretions such as saliva, bronchial mucus, seminal fluids, and gastrointestinal fluids, respectively. Increased expression and secretion of LF may play a significant role in the first line of host defense. One of the primary functions of LF is to scavenge free iron in fluids and inflamed areas to avoid free radical-facilitated damage. LF influences the proliferation, maturation, and activity of immune cells at the cellular level. LF plays a significant protective role in inflammation, oxidative stress, fibrosis, endoplasmic reticulum (ER) stress, autophagy dysfunction, and mitochondrial dysfunction. Also, LF was found protective against various pathologies including anemia, sepsis, and diarrhoea in clinical settings. This article reviews the protective role of LF against different pathophysiological conditions and its therapeutic advances as well as further research prospects. © 2021, Bangladesh Society for Microbiology, Immunology and Advanced Biotechnology. All rights reserved.
DOI
10.5455/jabet.2021.d123
Appears in Collections:
연구기관 > 약학연구소 > Journal papers
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