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Impact of an education program for caregivers of patients with Alzheimer’s disease on treatment discontinuation and compliance in Korea

Title
Impact of an education program for caregivers of patients with Alzheimer’s disease on treatment discontinuation and compliance in Korea
Authors
Kim H.-J.Shim Y.S.Park K.H.Lee C.-N.Jung S.Yoon S.J.Jeong S.-K.Jeong J.H.Choi S.H.Kim E.-J.Jang J.-W.Kang K.Yang Y.Kim S.
Ewha Authors
정지향
SCOPUS Author ID
정지향scopus
Issue Date
2021
Journal Title
Journal of Clinical Neurology (Korea)
ISSN
1738-6586JCR Link
Citation
Journal of Clinical Neurology (Korea) vol. 17, no. 3, pp. 368 - 375
Keywords
Alzheimer’s diseaseCaregiver educationDementiaKoreaTreatment compliance
Publisher
Korean Neurological Association
Indexed
SCIE; SCOPUS; KCI scopus
Document Type
Article
Abstract
Background and Purpose Reportedly 30–50% of patients being treated for chronic illnesses do not adhere to their medication regimen. We assessed the impact of a nurse-led education program for caregivers of Korean de novo Alzheimer’s disease patients who had newly been prescribed donepezil. Methods This multicenter study analyzed 93 participants in a caregiver education group and 92 participants in a caregiver no-education group. At every visit up to the end of the study (1 year), caregivers in the education group were given educational brochures regarding Alzheimer’s disease and the efficacy and adverse events of donepezil treatment. The primary endpoint was the discontinuation rate of donepezil treatment during the 1-year observation period. The secondary endpoints included the effect of education on compliance with donepezil treatment assessed at each visit using a clinician rating scale (CRS) and visual analog scale (VAS), and changes from baseline in cognitive assessment tests. Results The donepezil discontinuation rates at 1 year were 5.38% (5/93) and 6.52% (6/92) in the caregiver education and no-education groups, respectively (p=0.742). No significant between-group differences in donepezil compliance rates on the CRS and VAS were observed, but significant changes were observed in some cognitive tests from baseline to the end of the study. Conclusions Caregiver education had no significant effect on treatment discontinuation, but this may have been due to the low severity of cognitive impairment among the included population at baseline. In addition, the low discontinuation rates meant that no significant difference in treatment compliance was observed. © 2021 Korean Neurological Association.
DOI
10.3988/jcn.2021.17.3.368
Appears in Collections:
의과대학 > 의학과 > Journal papers
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