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의과대학
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Journal papers
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Sarcomatoid urothelial carcinoma arising in the female urethral diverticulum
Title
Sarcomatoid urothelial carcinoma arising in the female urethral diverticulum
Authors
Park H.S.
Ewha Authors
박혜성
SCOPUS Author ID
박혜성
Issue Date
2021
Journal Title
Journal of Pathology and Translational Medicine
ISSN
2383-7837
Citation
Journal of Pathology and Translational Medicine vol. 51, no. 3, pp. 298 - 302
Keywords
Sarcomatoid carcinoma
;
Urethral diverticulum
;
Urothelial carcinoma
Publisher
Seoul National University
Indexed
SCOPUS; KCI
Document Type
Article
Abstract
A sarcomatoid variant of urothelial carcinoma in the female urethral diverticulum has not been reported previously. A 66-year-old woman suffering from dysuria presented with a huge urethral mass invading the urinary bladder and vagina. Histopathological examination of the resected specimen revealed predominantly undifferentiated pleomorphic sarcoma with sclerosis. Only a small portion of conventional urothelial carcinoma was identified around the urethral diverticulum, which contained glandular epithelium and villous adenoma. The patient showed rapid systemic recurrence and resistance to immune checkpoint inhibitor therapy despite high expression of programmed cell death ligand-1. We report the first case of urethral diverticular carcinoma with sarcomatoid features. © 2021 The Korean Society of Pathologists/The Korean Society for Cytopathology.
DOI
10.4132/jptm.2021.04.23
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