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Overexpression of translationally controlled tumor protein ameliorates metabolic imbalance and increases energy expenditure in mice
- Title
- Overexpression of translationally controlled tumor protein ameliorates metabolic imbalance and increases energy expenditure in mice
- Authors
- Jeon Y.; Choi J.-Y.; Jang E.-H.; Seong J.K.; Lee K.
- Ewha Authors
- 이경림
- SCOPUS Author ID
- 이경림
- Issue Date
- 2021
- Journal Title
- International Journal of Obesity
- ISSN
- 0307-0565
- Citation
- International Journal of Obesity vol. 45, no. 7, pp. 1576 - 1587
- Publisher
- Springer Nature
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Background/Objectives: Translationally controlled tumor protein (TCTP) exhibits numerous biological functions. It has been shown to be involved in the regulation of glucose. However, its specific role in metabolism has not yet been clearly elucidated. Here, we aimed to assess the effect of TCTP overexpression on metabolic tissues and systemic energy metabolism. Subjects/Methods: We investigated whether TCTP can ameliorate the metabolic imbalance that causes obesity using TCTP-overexpressing transgenic (TCTP TG) mice. The mice were subjected to biochemical, morphological, physiological and protein expression studies to define the role of TCTP in metabolic regulation in response to normal chow diet (NCD) compared to high-fat diet (HFD) conditions, and cold environment. Results: We found that TCTP TG mice show improved metabolic homeostasis under both of NCD and HFD conditions with simultaneous enhancements in glucose tolerance and insulin sensitivity. In particular, we found coincident increases in energy expenditure with significant upregulation of uncoupling protein 1 (UCP1) in the brown adipose tissue (BAT). Moreover, TCTP overexpressing mice exhibit significantly enhanced adaptive thermogenesis of BAT in response to cold exposure. Conclusions: Overexpression of TCTP ameliorated systemic metabolic homeostasis by stimulating UCP1-mediated thermogenesis in the BAT. This suggests that TCTP may function as a modulator of energy expenditure. This study suggests TCTP may serve as a therapeutic target for obesity and obesity-associated metabolic disorders including type 2 diabetes. © 2021, The Author(s), under exclusive licence to Springer Nature Limited.
- DOI
- 10.1038/s41366-021-00821-6
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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