DSpace at EWHA: Dumulmycin, an antitubercular bicyclic macrolide from a riverine sediment-derived streptomyces sp.

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DSpace at EWHA자연과학대학 화학·나노과학전공 Journal papers

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DC Field	Value	Language
dc.contributor.author	남상집	*
dc.date.accessioned	2021-08-12T16:31:50Z	-
dc.date.available	2021-08-12T16:31:50Z	-
dc.date.issued	2021	*
dc.identifier.issn	1523-7060	*
dc.identifier.other	OAK-29483	*
dc.identifier.uri	https://dspace.ewha.ac.kr/handle/2015.oak/258715	-
dc.description.abstract	Dumulmycin (1) was isolated from Streptomyces sp. DM28, a bacterial strain from a riverine sediment sample. The structure of 1 was elucidated as a bicyclic macrolide possessing 19-membered and 5-membered rings by spectroscopic analysis. The stereochemistry of 1 was determined by J-based configuration analysis, ROESY NMR data, DP4 calculations, and the modified Mosher's method. Genetic analysis identified a trans-acyltransferase polyketide biosynthetic gene cluster for 1. Dumulmycin exhibited in vitro antitubercular activity (MIC50 = 27.1 μM). © 2021 American Chemical Society.	*
dc.language	English	*
dc.publisher	American Chemical Society	*
dc.title	Dumulmycin, an antitubercular bicyclic macrolide from a riverine sediment-derived streptomyces sp.	*
dc.type	Article	*
dc.relation.issue	9	*
dc.relation.volume	23	*
dc.relation.index	SCIE	*
dc.relation.index	SCOPUS	*
dc.relation.startpage	3359	*
dc.relation.lastpage	3363	*
dc.relation.journaltitle	Organic Letters	*
dc.identifier.doi	10.1021/acs.orglett.1c00847	*
dc.identifier.wosid	WOS:000649477300025	*
dc.identifier.scopusid	2-s2.0-85106162085	*
dc.author.google	An J.S.	*
dc.author.google	Shin B.	*
dc.author.google	Kim T.H.	*
dc.author.google	Hwang S.	*
dc.author.google	Shin Y.-H.	*
dc.author.google	Cui J.	*
dc.author.google	Du Y.E.	*
dc.author.google	Yi J.	*
dc.author.google	Nam S.-J.	*
dc.author.google	Hong S.	*
dc.author.google	Shin J.	*
dc.author.google	Jang J.	*
dc.author.google	Yoon Y.J.	*
dc.author.google	Oh D.-C.	*
dc.contributor.scopusid	남상집(57208839798)	*
dc.date.modifydate	20240220120010	*