Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김준수 | * |
dc.date.accessioned | 2021-08-12T16:31:07Z | - |
dc.date.available | 2021-08-12T16:31:07Z | - |
dc.date.issued | 2021 | * |
dc.identifier.issn | 2470-1343 | * |
dc.identifier.other | OAK-29885 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/258648 | - |
dc.description.abstract | We present extensive molecular dynamics simulations of a cationic nanoparticle and a double-stranded DNA molecule to discuss the effect of DNA flexibility on the complex formation of a cationic nanoparticle with double-stranded DNA. Martini coarse-grained models were employed to describe double-stranded DNA molecules with two different flexibilities and cationic nanoparticles with three different electric charges. As the electric charge of a cationic nanoparticle increases, the degree of DNA bending increases, eventually leading to the wrapping of DNA around the nanoparticle at high electric charges. However, a small increase in the persistence length of DNA by 10 nm requires a cationic nanoparticle with a markedly increased electric charge to bend and wrap DNA around. Thus, a more flexible DNA molecule bends and wraps around a cationic nanoparticle with an intermediate electric charge, whereas a less flexible DNA molecule binds to a nanoparticle with the same electric charge without notable bending. This work provides solid evidence that a small difference in DNA flexibility (as small as 10 nm in persistence length) has a substantial influence on the complex formation of DNA with proteins from a biological perspective and suggests that the variation of sequence-dependent DNA flexibility can be utilized in DNA nanotechnology as a new tool to manipulate the structure of DNA molecules mediated by nanoparticle binding. | * |
dc.language | English | * |
dc.publisher | AMER CHEMICAL SOC | * |
dc.title | Effect of DNA Flexibility on Complex Formation of a Cationic Nanoparticle with Double-Stranded DNA | * |
dc.type | Article | * |
dc.relation.issue | 29 | * |
dc.relation.volume | 6 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 18728 | * |
dc.relation.lastpage | 18736 | * |
dc.relation.journaltitle | ACS OMEGA | * |
dc.identifier.doi | 10.1021/acsomega.1c01709 | * |
dc.identifier.wosid | WOS:000679374200018 | * |
dc.author.google | Bae, Sehui | * |
dc.author.google | Oh, Inrok | * |
dc.author.google | Yoo, Jejoong | * |
dc.author.google | Kim, Jun Soo | * |
dc.contributor.scopusid | 김준수(23670121600) | * |
dc.date.modifydate | 20240215165024 | * |