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dc.contributor.author서원효*
dc.date.accessioned2021-08-12T16:30:57Z-
dc.date.available2021-08-12T16:30:57Z-
dc.date.issued2020*
dc.identifier.issn1550-4131*
dc.identifier.issn1932-7420*
dc.identifier.otherOAK-29992*
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/258604-
dc.description.abstractObesity is a top public health concern, and a molecule that safely treats obesity is urgently needed. Disulfiram (known commercially as Antabuse), an FDA-approved treatment for chronic alcohol addiction, exhibits anti-inflammatory properties and helps protect against certain types of cancer. Here, we show that in mice disul-firam treatment prevented body weight gain and abrogated the adverse impact of an obesogenic diet on in-sulin responsiveness while mitigating liver steatosis and pancreatic islet hypertrophy. Additionally, disulfiram treatment reversed established diet-induced obesity and metabolic dysfunctions in middle-aged mice. Re-ductions in feeding efficiency and increases in energy expenditure were associated with body weight regu-lation in response to long-term disulfiram treatment. Loss of fat tissue and an increase in liver fenestrations were also observed in rats on disulfiram. Given the potent anti-obesogenic effects in rodents, repurposing disulfiram in the clinic could represent a new strategy to treat obesity and its metabolic comorbidities.*
dc.languageEnglish*
dc.publisherCELL PRESS*
dc.titleDisulfiram Treatment Normalizes Body Weight in Obese Mice*
dc.typeArticle*
dc.relation.issue2*
dc.relation.volume32*
dc.relation.indexSCIE*
dc.relation.indexSCOPUS*
dc.relation.startpage203*
dc.relation.lastpage+*
dc.relation.journaltitleCELL METABOLISM*
dc.identifier.doi10.1016/j.cmet.2020.04.019*
dc.identifier.wosidWOS:000555970500008*
dc.author.googleBernier, Michel*
dc.author.googleMitchell, Sarah J.*
dc.author.googleWahl, Devin*
dc.author.googleDiaz, Antonio*
dc.author.googleSingh, Abhishek*
dc.author.googleSeo, Wonhyo*
dc.author.googleWang, Mingy*
dc.author.googleAli, Ahmed*
dc.author.googleKaiser, Tamzin*
dc.author.googlePrice, Nathan L.*
dc.author.googleAon, Miguel A.*
dc.author.googleKim, Eun-Young*
dc.author.googlePetr, Michael A.*
dc.author.googleCai, Huan*
dc.author.googleWarren, Alessa*
dc.author.googleDi Germanio, Clara*
dc.author.googleDi Francesco, Andrea*
dc.author.googleFishbein, Ken*
dc.author.googleGuiterrez, Vince*
dc.author.googleHarney, Dylan*
dc.author.googleKoay, Yen Chin*
dc.author.googleMach, John*
dc.author.googleEnamorado, Ignacio Navas*
dc.author.googlePulpitel, Tamara*
dc.author.googleWang, Yushi*
dc.author.googleZhang, Jing*
dc.author.googleZhang, Li*
dc.author.googleSpencer, Richard G.*
dc.author.googleBecker, Kevin G.*
dc.author.googleEgan, Josephine M.*
dc.author.googleLakatta, Edward G.*
dc.author.googleO'Sullivan, John*
dc.author.googleLarance, Mark*
dc.author.googleLeCouteur, David G.*
dc.author.googleCogger, Victoria C.*
dc.author.googleGao, Bin*
dc.author.googleFernandez-Hernando, Carlos*
dc.author.googleCuervo, Ana Maria*
dc.author.googlede Cabo, Rafael*
dc.contributor.scopusid서원효(56335935100)*
dc.date.modifydate20240315114146*
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약학대학 > 약학과 > Journal papers
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