Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서원효 | * |
dc.date.accessioned | 2021-08-12T16:30:57Z | - |
dc.date.available | 2021-08-12T16:30:57Z | - |
dc.date.issued | 2020 | * |
dc.identifier.issn | 1550-4131 | * |
dc.identifier.issn | 1932-7420 | * |
dc.identifier.other | OAK-29992 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/258604 | - |
dc.description.abstract | Obesity is a top public health concern, and a molecule that safely treats obesity is urgently needed. Disulfiram (known commercially as Antabuse), an FDA-approved treatment for chronic alcohol addiction, exhibits anti-inflammatory properties and helps protect against certain types of cancer. Here, we show that in mice disul-firam treatment prevented body weight gain and abrogated the adverse impact of an obesogenic diet on in-sulin responsiveness while mitigating liver steatosis and pancreatic islet hypertrophy. Additionally, disulfiram treatment reversed established diet-induced obesity and metabolic dysfunctions in middle-aged mice. Re-ductions in feeding efficiency and increases in energy expenditure were associated with body weight regu-lation in response to long-term disulfiram treatment. Loss of fat tissue and an increase in liver fenestrations were also observed in rats on disulfiram. Given the potent anti-obesogenic effects in rodents, repurposing disulfiram in the clinic could represent a new strategy to treat obesity and its metabolic comorbidities. | * |
dc.language | English | * |
dc.publisher | CELL PRESS | * |
dc.title | Disulfiram Treatment Normalizes Body Weight in Obese Mice | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 32 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 203 | * |
dc.relation.lastpage | + | * |
dc.relation.journaltitle | CELL METABOLISM | * |
dc.identifier.doi | 10.1016/j.cmet.2020.04.019 | * |
dc.identifier.wosid | WOS:000555970500008 | * |
dc.author.google | Bernier, Michel | * |
dc.author.google | Mitchell, Sarah J. | * |
dc.author.google | Wahl, Devin | * |
dc.author.google | Diaz, Antonio | * |
dc.author.google | Singh, Abhishek | * |
dc.author.google | Seo, Wonhyo | * |
dc.author.google | Wang, Mingy | * |
dc.author.google | Ali, Ahmed | * |
dc.author.google | Kaiser, Tamzin | * |
dc.author.google | Price, Nathan L. | * |
dc.author.google | Aon, Miguel A. | * |
dc.author.google | Kim, Eun-Young | * |
dc.author.google | Petr, Michael A. | * |
dc.author.google | Cai, Huan | * |
dc.author.google | Warren, Alessa | * |
dc.author.google | Di Germanio, Clara | * |
dc.author.google | Di Francesco, Andrea | * |
dc.author.google | Fishbein, Ken | * |
dc.author.google | Guiterrez, Vince | * |
dc.author.google | Harney, Dylan | * |
dc.author.google | Koay, Yen Chin | * |
dc.author.google | Mach, John | * |
dc.author.google | Enamorado, Ignacio Navas | * |
dc.author.google | Pulpitel, Tamara | * |
dc.author.google | Wang, Yushi | * |
dc.author.google | Zhang, Jing | * |
dc.author.google | Zhang, Li | * |
dc.author.google | Spencer, Richard G. | * |
dc.author.google | Becker, Kevin G. | * |
dc.author.google | Egan, Josephine M. | * |
dc.author.google | Lakatta, Edward G. | * |
dc.author.google | O'Sullivan, John | * |
dc.author.google | Larance, Mark | * |
dc.author.google | LeCouteur, David G. | * |
dc.author.google | Cogger, Victoria C. | * |
dc.author.google | Gao, Bin | * |
dc.author.google | Fernandez-Hernando, Carlos | * |
dc.author.google | Cuervo, Ana Maria | * |
dc.author.google | de Cabo, Rafael | * |
dc.contributor.scopusid | 서원효(56335935100) | * |
dc.date.modifydate | 20240315114146 | * |