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Machine learning approaches for predicting bisphosphonate-related osteonecrosis in women with osteoporosis using vegfa gene polymorphisms
- Title
- Machine learning approaches for predicting bisphosphonate-related osteonecrosis in women with osteoporosis using vegfa gene polymorphisms
- Authors
- Kim J.-W.; Yee J.; Oh S.-H.; Kim S.-H.; Kim S.-J.; Chung J.-E.; Gwak H.-S.
- Ewha Authors
- 곽혜선; 김선종; 김진우
- SCOPUS Author ID
- 김선종; 김진우
- Issue Date
- 2021
- Journal Title
- Journal of Personalized Medicine
- ISSN
- 2075-4426
- Citation
- Journal of Personalized Medicine vol. 11, no. 6
- Keywords
- Bisphosphonate-related osteonecrosis; Gene polymorphism; Machine learning; VEGFA
- Publisher
- MDPI AG
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Objective: This nested case–control study aimed to investigate the effects of VEGFA poly-morphisms on the development of bisphosphonate-related osteonecrosis of the jaw (BRONJ) in women with osteoporosis. Methods: Eleven single nucleotide polymorphisms (SNPs) of the VEGFA were assessed in a total of 125 patients. Logistic regression was performed for multivariable analy-sis. Machine learning algorithms, namely, fivefold cross-validated multivariate logistic regression, elastic net, random forest, and support vector machine, were developed to predict risk factors for BRONJ occurrence. Area under the receiver-operating curve (AUROC) analysis was conducted to assess clinical performance. Results: The VEGFA rs881858 was significantly associated with BRONJ development. The odds of BRONJ development were 6.45 times (95% CI, 1.69–24.65) higher among carriers of the wild-type rs881858 allele compared with variant homozygote carriers after adjusting for covariates. Additionally, variant homozygote (GG) carriers of rs10434 had higher odds than those with wild-type allele (OR, 3.16). Age ≥ 65 years (OR, 16.05) and bisphosphonate exposure ≥ 36 months (OR, 3.67) were also significant risk factors for BRONJ occurrence. AUROC values were higher than 0.78 for all machine learning methods employed in this study. Conclusion: Our study showed that the BRONJ occurrence was associated with VEGFA polymorphisms in osteoporotic women. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
- DOI
- 10.3390/jpm11060541
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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