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Cost-Effectiveness, Efficacy, and Safety Analysis of Tailored Therapy in Patients with Helicobacter pylori Infection

Title
Cost-Effectiveness, Efficacy, and Safety Analysis of Tailored Therapy in Patients with Helicobacter pylori Infection
Authors
Choe, A. ReumShim, Ki-NamPark, YehyunSong, Eun-MiTae, Chung HyunJung, Sung-Ae
Ewha Authors
정성애심기남태정현송은미박예현최아름
SCOPUS Author ID
정성애scopusscopus; 심기남scopus; 태정현scopus; 송은미scopus; 박예현scopus; 최아름scopus
Issue Date
2021
Journal Title
JOURNAL OF CLINICAL MEDICINE
ISSN
2077-0383JCR Link
Citation
JOURNAL OF CLINICAL MEDICINE vol. 10, no. 12
Keywords
Helicobacter pylorieradicationantibiotic resistancetailoredempirical
Publisher
MDPI
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
Recently in Korea, where triple therapy is accepted as the first-line Helicobacter pylori (H. pylori) eradication treatment, antibiotic resistance to clarithromycin has increased considerably, resulting in eradication rates of less than 80%. We investigated the efficacy of tailored therapy after a clarithromycin resistance test compared with empirical therapy for H. pylori eradication. The cost-effectiveness of H. pylori eradication success was evaluated according to the average medical cost per patient. A total of 364 patients were enrolled in the study. The first-line H. pylori eradication rate was significantly higher in patients who received tailored therapy than in those who received empirical therapy. The total medical costs for the tailored and empirical groups were 46,374 Won and 53,528 Won. The total treatment period for each ultimately successful eradication in the tailored group was 79.8 +/- 2.8 days, which is shorter than that of the empirical group (99.2 +/- 7.4 days). The rate of eradication-related adverse events for the tailored group and empirical group was 12.9% and 14.8%, respectively. Tailored therapy could be a useful option to achieve a higher successful eradication rate, shorter treatment periods, and lower medical costs than empirical therapy in the era of increasing antibiotic resistance.
DOI
10.3390/jcm10122619
Appears in Collections:
의과대학 > 의학과 > Journal papers
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