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Cost-Effectiveness, Efficacy, and Safety Analysis of Tailored Therapy in Patients with Helicobacter pylori Infection
- Title
- Cost-Effectiveness, Efficacy, and Safety Analysis of Tailored Therapy in Patients with Helicobacter pylori Infection
- Authors
- Choe, A. Reum; Shim, Ki-Nam; Park, Yehyun; Song, Eun-Mi; Tae, Chung Hyun; Jung, Sung-Ae
- Ewha Authors
- 정성애; 심기남; 태정현; 송은미; 박예현; 최아름
- SCOPUS Author ID
- 정성애; 심기남; 태정현; 송은미; 박예현; 최아름
- Issue Date
- 2021
- Journal Title
- JOURNAL OF CLINICAL MEDICINE
- ISSN
- 2077-0383
- Citation
- JOURNAL OF CLINICAL MEDICINE vol. 10, no. 12
- Keywords
- Helicobacter pylori; eradication; antibiotic resistance; tailored; empirical
- Publisher
- MDPI
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Recently in Korea, where triple therapy is accepted as the first-line Helicobacter pylori (H. pylori) eradication treatment, antibiotic resistance to clarithromycin has increased considerably, resulting in eradication rates of less than 80%. We investigated the efficacy of tailored therapy after a clarithromycin resistance test compared with empirical therapy for H. pylori eradication. The cost-effectiveness of H. pylori eradication success was evaluated according to the average medical cost per patient. A total of 364 patients were enrolled in the study. The first-line H. pylori eradication rate was significantly higher in patients who received tailored therapy than in those who received empirical therapy. The total medical costs for the tailored and empirical groups were 46,374 Won and 53,528 Won. The total treatment period for each ultimately successful eradication in the tailored group was 79.8 +/- 2.8 days, which is shorter than that of the empirical group (99.2 +/- 7.4 days). The rate of eradication-related adverse events for the tailored group and empirical group was 12.9% and 14.8%, respectively. Tailored therapy could be a useful option to achieve a higher successful eradication rate, shorter treatment periods, and lower medical costs than empirical therapy in the era of increasing antibiotic resistance.
- DOI
- 10.3390/jcm10122619
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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