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Photo-Fenozyme Nanoparticles Based on Fe(II)-Coordination-Driven Cyanine-Based Amino Acid Assembly for Photodynamic Ferrotherapy
- Title
- Photo-Fenozyme Nanoparticles Based on Fe(II)-Coordination-Driven Cyanine-Based Amino Acid Assembly for Photodynamic Ferrotherapy
- Authors
- Han, Jingjing; Kang, Hyunchul; Li, Xingshu; Kwon, Nahyun; Li, Haidong; Park, Sungnam; Yoon, Juyoung
- Ewha Authors
- 윤주영
- SCOPUS Author ID
- 윤주영
- Issue Date
- 2021
- Journal Title
- ACS APPLIED NANO MATERIALS
- ISSN
- 2574-0970
- Citation
- ACS APPLIED NANO MATERIALS vol. 4, no. 6, pp. 5954 - 5962
- Keywords
- Fe(II)-coordination-driven Co-assembly; photosensitizer; self-evolution; photosensitive nanoparticles; ferrotherapeutic agent
- Publisher
- AMER CHEMICAL SOC
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Nanoparticle-based enzyme mimics have fewer applications in ferrotherapy so far. The limited number of integrated biomimetic architectures satisfy biobuilding blocks and adaptability in the high efficiency of ferrotherapy requirements. Herein, we develop a minimal nanoparticle as an efficient photodynamic ferrotherapy agent, which is constructed through ferrous-coordination-driven cyanine-based amino acid assembly. In comparison with a free photosensitizer, this nanoparticle (photo-fenozyme) composed of Fe-containing cores and serum protein shells is fabricated. And it has a high light-harvesting ability, and a higher intersystem crossing (ISC) rate constant (4.41 X 10(11) s(-1) versus 1.17 x 10(6) s(-1)), which benefits efficient production of the triplet state. The photofenozyme allows adaptive photo-Fentonlike activity based on the different radical generations. And they further trigger and photoenhance efficient ferroptosis. This work provides insights into optimizing current photosensitizers to generate an adaptive supramolecular photocatalyst and presents a promising strategy to design multifunctional nanozyme theranostics.
- DOI
- 10.1021/acsanm.1c00843
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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