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An Insight into Pathophysiological Features and Therapeutic Advances on Ependymoma

Title
An Insight into Pathophysiological Features and Therapeutic Advances on Ependymoma
Authors
Seo, Seung-HeePaul, Shamrat KumarShikder, MitaKhanam, MushiraGhosh, PopyHasib, Tasnin AlAhmed, Kazi AhsanSikdar, SuranjanaUddin, Md JamalKwon, Youngjoo
Ewha Authors
권영주Md Jamal Uddin
SCOPUS Author ID
권영주scopus; Md Jamal Uddinscopus
Issue Date
2021
Journal Title
CANCERS
ISSN
2072-6694JCR Link
Citation
CANCERS vol. 13, no. 13
Keywords
brain tumorependymomaoncogenetumor diagnosistumor treatment
Publisher
MDPI
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Review
Abstract
Simple Summary Although biological information and the molecular classification of ependymoma have been studied, the treatment systems for ependymoma are still insufficient. In addition, because the disease occurs infrequently, it is difficult to obtain sufficient data to conduct large-scale or randomized clinical trials. Therefore, this study is intended to emphasize the importance of understanding its pathological characteristics and prognosis as well as developing treatments for ependymoma through multilateral studies. Glial cells comprise the non-sensory parts of the central nervous system as well as the peripheral nervous system. Glial cells, also known as neuroglia, constitute a significant portion of the mammalian nervous system and can be viewed simply as a matrix of neural cells. Despite being the "Nervenkitt" or "glue of the nerves", they aptly serve multiple roles, including neuron repair, myelin sheath formation, and cerebrospinal fluid circulation. Ependymal cells are one of four kinds of glial cells that exert distinct functions. Tumorigenesis of a glial cell is termed a glioma, and in the case of an ependymal cell, it is called an ependymoma. Among the various gliomas, an ependymoma in children is one of the more challenging brain tumors to cure. Children are afflicted more severely by ependymal tumors than adults. It has appeared from several surveys that ependymoma comprises approximately six to ten percent of all tumors in children. Presently, the surgical removal of the tumor is considered a standard treatment for ependymomas. It has been conspicuously evident that a combination of irradiation therapy and surgery is much more efficacious in treating ependymomas. The main purpose of this review is to present the importance of both a deep understanding and ongoing research into histopathological features and prognoses of ependymomas to ensure that effective diagnostic methods and treatments can be developed.
DOI
10.3390/cancers13133221
Appears in Collections:
약학대학 > 약학과 > Journal papers
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