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Association of physical activity with the risk of hepatocellular carcinoma in patients with chronic hepatitis b
- Title
- Association of physical activity with the risk of hepatocellular carcinoma in patients with chronic hepatitis b
- Authors
- Chun H.S.; Park S.; Lee M.; Cho Y.; Kim H.S.; Choe A.R.; Kim H.Y.; Yoo K.; Kim T.H.
- Ewha Authors
- 유권; 김태헌; 김휘영; 이민종; 최아름
- SCOPUS Author ID
- 유권; 김태헌; 김휘영; 이민종; 최아름
- Issue Date
- 2021
- Journal Title
- Cancers
- ISSN
- 2072-6694
- Citation
- Cancers vol. 13, no. 14
- Keywords
- Chronic hepatitis B; Hepatocellular carcinoma; Physical activity
- Publisher
- MDPI AG
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Background and Aims: In the general population, previous studies reported that physical activity was associated with risk of hepatocellular carcinoma (HCC) development. However, it is unclear whether physical activity is associated with risk of HCC development in patients with chronic hepatitis B (CHB). We aimed to elucidate the association between physical activity and risk of HCC development in CHB patients. Methods: This nationwide cohort study involved treatmentnaive patients with CHB (n = 9727) who started treatment with entecavir or tenofovir and answered self-reported questionnaires between January 2012 and December 2017, using data from the Korean National Health Insurance Service database. The primary endpoint was development of HCC. Multivariable Cox regression and competing risk analyses were used. Results: During a median follow-up of 3.1 years, cumulative HCC incidence rates were 8.3%. There was an inverse association between physical activity and the risk of HCC (p < 0.001). Patients with 1000–1500 metabolic equivalent task (MET)-min/week, compared to those without physical activity, showed a significantly lower risk of HCC in both patients without cirrhosis (adjusted hazard ratio [aHR] 0.66, p = 0.02) and patients with cirrhosis (aHR 0.61, p = 0.02). In patients who were younger (<60), male, without diabetes, and with high BMI, amounts of physical activity of 1000–1500 MET-min/week showed an inverse association with the risk of HCC (aHR 0.65, 0.63, 0.65, and 0.64, respectively, all p < 0.05). Conclusion: Physical activity was significantly associated with a low risk of HCC in CHB patients treated with entecavir or tenofovir. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
- DOI
- 10.3390/cancers13143424
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
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cancers-13-03424.pdf(1.46 MB)
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