Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 강상원 | * |
dc.date.accessioned | 2021-08-05T16:31:01Z | - |
dc.date.available | 2021-08-05T16:31:01Z | - |
dc.date.issued | 2021 | * |
dc.identifier.issn | 0278-6915 | * |
dc.identifier.issn | 1873-6351 | * |
dc.identifier.other | OAK-29714 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/258437 | - |
dc.description.abstract | We suggested that selenium-dependent glutathione peroxidase (GPx) plays a protective role against methamphetamine (MA)-induced dopaminergic toxicity. We focused on GPx-1, a major selenium-dependent enzyme and constructed a GPx-1 gene-encoded adenoviral vector (Ad-GPx-1) to delineate the role of GPx-1 in MA-induced dopaminergic neurotoxicity. Exposure to Ad-GPx-1 significantly induced GPx activity and GPx-1 protein levels in GPx-1-knockout (GPx-1-KO) mice. MA-induced dopaminergic impairments [i.e., hyperthermia; increased nuclear factor kappa-light-chain-enhancer of activated B cells (NF-KB) DNA-binding activity; and decreased dopamine levels, TH activity, and behavioral activity] were more pronounced in GPx-1-KO mice than in WT mice. In contrast, exposure to Ad-GPx-1 significantly attenuated MA-induced dopaminergic loss in GPx-1-KO mice. The protective effect exerted by Ad-GPx-1 was comparable to that exerted by pyrrolidine dithiocarbamate (PDTC), an NF-KB inhibitor against MA insult. Consistently, GPx-1 overexpression significantly attenuated MA dopaminergic toxicity in mice. PDTC did not significantly impact the protective effect of GPx-1 overexpression, suggesting that interaction between NF-KB and GPx-1 is critical for dopaminergic protection. Thus, NF-KB is a potential therapeutic target for GPx-1-mediated dopaminergic protective activity. This study for the first time demonstrated that Ad-GPx-1 rescued dopaminergic toxicity in vivo following MA insult. Furthermore, GPx-1associated therapeutic interventions may be important against dopaminergic toxicity. | * |
dc.language | English | * |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | * |
dc.subject | GPx-1 gene-encoded adenoviral vector | * |
dc.subject | GPx-1 knockout mice | * |
dc.subject | GPx-1 overexpressing transgenic mice | * |
dc.subject | NF-KB inhibitor | * |
dc.subject | Striatum | * |
dc.subject | Methamphetamine-induced dopaminergic&nbsp | * |
dc.subject | toxicity | * |
dc.title | GPx-1-encoded adenoviral vector attenuates dopaminergic impairments induced by methamphetamine in GPx-1 knockout mice through modulation of NF-KB transcription factor | * |
dc.type | Article | * |
dc.relation.volume | 154 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | FOOD AND CHEMICAL TOXICOLOGY | * |
dc.identifier.doi | 10.1016/j.fct.2021.112313 | * |
dc.identifier.wosid | WOS:000677525600002 | * |
dc.identifier.scopusid | 2-s2.0-85107540969 | * |
dc.author.google | Sharma, Naveen | * |
dc.author.google | Shin, Eun-Joo | * |
dc.author.google | Duc Toan Pham | * |
dc.author.google | Sharma, Garima | * |
dc.author.google | Duy-Khanh Dang | * |
dc.author.google | Chu Xuan Duong | * |
dc.author.google | Kang, Sang Won | * |
dc.author.google | Nah, Seung-Yeol | * |
dc.author.google | Jang, Choon-Gon | * |
dc.author.google | Lei, Xin Gen | * |
dc.author.google | Nabeshima, Toshitaka | * |
dc.author.google | Bing, Guoying | * |
dc.author.google | Jeong, Ji Hoon | * |
dc.author.google | Kim, Hyoung-Chun | * |
dc.contributor.scopusid | 강상원(55731433900) | * |
dc.date.modifydate | 20240118155300 | * |