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Serum Lactate Could Predict Mortality in Patients With Spontaneous Subarachnoid Hemorrhage in the Emergency Department

Title
Serum Lactate Could Predict Mortality in Patients With Spontaneous Subarachnoid Hemorrhage in the Emergency Department
Authors
Oh, Chang HwanKim, Jong WonKim, Geon HaLee, Kyeong RyongHong, Dae YoungPark, Sang O.Baek, Kwang JeKim, Sin Young
Ewha Authors
김건하
Issue Date
2020
Journal Title
FRONTIERS IN NEUROLOGY
ISSN
1664-2295JCR Link
Citation
FRONTIERS IN NEUROLOGY vol. 11
Keywords
lactatesubarachnoid hemorrhageaneurysmmortalityemergency department
Publisher
FRONTIERS MEDIA SA
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Background:Serum lactate is a useful biomarker for prediction of mortality in critically ill patients. The purpose of this study was to identify if serum lactate could be used as a biomarker for predicting mortality in patients with subarachnoid hemorrhage (SAH) in the emergency department. Methods:This retrospective study enrolled 189 patients. Baseline demographic data and clinical characteristics of patients were obtained from medical record review. Multiple logistic regression analysis was performed to determine predictor variables significantly associated with mortality. Receiver operating characteristic (ROC) curve analysis was used to evaluate the performance of variables for mortality prediction in SAH. Results:Using multivariate logistic regression analysis, age [OR 1.05; 95% confidence interval (CI) 1.00-1.10;p= 0.037], Hunt and Hess scale score (OR 3.29; 95% CI 1.62-6.70;p= 0.001), serum lactate level (OR 1.33; 95% CI 1.03-1.74;p= 0.032), and serum glucose level (OR 1.01; 95% CI 1.00-1.02;p= 0.049) predicted overall mortality in SAH. The area under the ROC curve (AUC) value for the use of serum lactate level to predict mortality in SAH was 0.815 (95% CI 0.753-0.868) (p< 0.001). Conclusion:Serum lactate may be a useful biomarker for the early prediction of mortality in SAH patients in the emergency department.
DOI
10.3389/fneur.2020.00975
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의료원 > 의료원 > Journal papers
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