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The mechanistic GEMMs of oncogenic histones

Title
The mechanistic GEMMs of oncogenic histones
Authors
Lindroth, Anders M.Jung Park, YoonMatia, VeronicaSquatrito, Massimo
Ewha Authors
박윤정
SCOPUS Author ID
박윤정scopus
Issue Date
2020
Journal Title
HUMAN MOLECULAR GENETICS
ISSN
0964-6906JCR Link

1460-2083JCR Link
Citation
HUMAN MOLECULAR GENETICS vol. 29, no. R2, pp. R226 - R235
Publisher
OXFORD UNIV PRESS
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Review
Abstract
The last decade's progress unraveling the mutational landscape of all age groups of cancer has uncovered mutations in histones as vital contributors of tumorigenesis. Here we review three new aspects of oncogenic histones: first, the identification of additional histone mutations potentially contributing to cancer formation; second, tumors expressing histone mutations to study the crosstalk of post-translational modifications, and; third, development of sophisticated biological model systems to reproduce tumorigenesis. At the outset, we recapitulate the firstly discovered histone mutations in pediatric and adolescent tumors of the brain and bone, which still remain the most pronounced histone alterations in cancer. We branch out to discuss the ramifications of histone mutations, including novel ones, that stem from altered protein-protein interactions of cognate histone modifiers as well as the stability of the nucleosome. We close by discussing animal models of oncogenic histones that reproduce tumor formation molecularly and morphologically and the prospect of utilizing them for drug testing, leading to efficient treatment and cure of deadly cancers with histone mutations.
DOI
10.1093/hmg/ddaa143
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신산업융합대학 > 식품영양학과 > Journal papers
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