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Impact of Energy and Access Methods on Extrahepatic Tumor Spreading and the Ablation Zone: An Ex vivo Experiment Using a Subcapsular Tumor Model

Title
Impact of Energy and Access Methods on Extrahepatic Tumor Spreading and the Ablation Zone: An Ex vivo Experiment Using a Subcapsular Tumor Model
Authors
Kim, Jin SilKo, YoungsunKwon, HyeyoungKim, MinjeongLee, Jeong Kyong
Ewha Authors
이정경김진실
SCOPUS Author ID
이정경scopus; 김진실scopus
Issue Date
2019
Journal Title
KOREAN JOURNAL OF RADIOLOGY
ISSN
1229-6929JCR Link

2005-8330JCR Link
Citation
KOREAN JOURNAL OF RADIOLOGY vol. 20, no. 4, pp. 580 - 588
Keywords
Radiofrequency ablationThermal ablationExperimental liver neoplasmNeoplasm seeding
Publisher
KOREAN RADIOLOGICAL SOC
Indexed
SCIE; SCOPUS; KCI WOS scopus
Document Type
Article
Abstract
Objective: To evaluate the impact of energy and access methods on extrahepatic tumor spreading and the ablation zone in an ex vivo subcapsular tumor mimic model with a risk of extrahepatic tumor spreading. Materials and Methods: Forty-two tumor-mimics were created in bovine liver blocks by injecting a mixture of iodine contrast material just below the liver capsule. Radiofrequency (RF) ablations were performed using an electrode placed parallel or perpendicular to hepatic surface through the tumor mimic with low- and high-power protocols (groups 1 and 2, respectively). Computed tomography (CT) scans were performed before and after ablation. The presence of contrast leak on the hepatic surface on CT, size of ablation zone, and timing of the first roll-off and popping sound were compared between the groups. Results: With parallel access, one contrast leak in group 1 (1/10, 10%) and nine in group 2 (9/10, 90%) (p < 0.001) were identified on post-ablation CT. With perpendicular access, six contrast leaks were identified in each group (6/11, 54.5%). The first roll-off and popping sound were significantly delayed in group 1 irrespective of the access method (p = 0.002). No statistical difference in the size of the ablation zone of the liver specimen was observed between the two groups (p = 0.247). Conclusion: Low-power RF ablation with parallel access is proposed to be effective and safe from extrahepatic tumor spreading in RF ablation of a solid hepatic tumor in the subcapsular location. Perpendicular placement of an electrode to the capsule is associated with a risk of extrahepatic tumor spreading regardless of the power applied.
DOI
10.3348/kjr.2018.0564
Appears in Collections:
의과대학 > 의학과 > Journal papers
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