View : 35 Download: 0
Antihypertensive Drugs and the Risk of Cancer: A Nationwide Cohort Study
- Antihypertensive Drugs and the Risk of Cancer: A Nationwide Cohort Study
- Cho, In-Jeong; Shin, Jeong-Hun; Jung, Mi-Hyang; Kang, Chae Young; Hwang, Jinseub; Kwon, Chang Hee; Kim, Woohyeun; Kim, Dae-Hee; Lee, Chan Joo; Kang, Si-Hyuck; Lee, Ju-Hee; Kim, Hack-Lyoung; Kim, Hyue Mee; Cho, Iksung; Lee, Hae-Young; Chung, Wook-Jin; Ihm, Sang-Hyun; Kim, Kwang Il; Cho, Eun Joo; Sohn, Il-Suk; Park, Sungha; Shin, Jinho; Ryu, Sung Kee; Kim, Jang Young; Kang, Seok-Min; Cho, Myeong-Chan; Pyun, Wook Bum; Sung, Ki-Chul
- Ewha Authors
- 편욱범; 조인정
- SCOPUS Author ID
- 편욱범; 조인정
- Issue Date
- Journal Title
- JOURNAL OF CLINICAL MEDICINE
- JOURNAL OF CLINICAL MEDICINE vol. 10, no. 4
- antihypertensive agent; neoplasms; cohort study
- SCIE; SCOPUS
- Document Type
Show the fulltext
- We sought to assess the association between common antihypertensive drugs and the risk of incident cancer in treated hypertensive patients. Using the Korean National Health Insurance Service database, the risk of cancer incidence was analyzed in patients with hypertension who were initially free of cancer and used the following antihypertensive drug classes: Angiotensin-converting enzyme inhibitors (ACEIs); angiotensin receptor blockers (ARBs); beta blockers (BBs); calcium channel blockers (CCBs); and diuretics. During a median follow-up of 8.6 years, there were 4513 (6.4%) overall cancer incidences from an initial 70,549 individuals taking antihypertensive drugs. ARB use was associated with a decreased risk for overall cancer in a crude model (hazard ratio (HR): 0.744, 95% confidence interval (CI): 0.696-0.794) and a fully adjusted model (HR: 0.833, 95% CI: 0.775-0.896) compared with individuals not taking ARBs. Other antihypertensive drugs, including ACEIs, CCBs, BBs, and diuretics, did not show significant associations with incident cancer overall. The long-term use of ARBs was significantly associated with a reduced risk of incident cancer over time. The users of common antihypertensive medications were not associated with an increased risk of cancer overall compared to users of other classes of antihypertensive drugs. ARB use was independently associated with a decreased risk of cancer overall compared to other antihypertensive drugs.
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.