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Antihypertensive Drugs and the Risk of Cancer: A Nationwide Cohort Study

Title
Antihypertensive Drugs and the Risk of Cancer: A Nationwide Cohort Study
Authors
Cho, In-JeongShin, Jeong-HunJung, Mi-HyangKang, Chae YoungHwang, JinseubKwon, Chang HeeKim, WoohyeunKim, Dae-HeeLee, Chan JooKang, Si-HyuckLee, Ju-HeeKim, Hack-LyoungKim, Hyue MeeCho, IksungLee, Hae-YoungChung, Wook-JinIhm, Sang-HyunKim, Kwang IlCho, Eun JooSohn, Il-SukPark, SunghaShin, JinhoRyu, Sung KeeKim, Jang YoungKang, Seok-MinCho, Myeong-ChanPyun, Wook BumSung, Ki-Chul
Ewha Authors
편욱범조인정
SCOPUS Author ID
편욱범scopus; 조인정scopusscopus
Issue Date
2021
Journal Title
JOURNAL OF CLINICAL MEDICINE
ISSN
2077-0383JCR Link
Citation
JOURNAL OF CLINICAL MEDICINE vol. 10, no. 4
Keywords
antihypertensive agentneoplasmscohort study
Publisher
MDPI
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
We sought to assess the association between common antihypertensive drugs and the risk of incident cancer in treated hypertensive patients. Using the Korean National Health Insurance Service database, the risk of cancer incidence was analyzed in patients with hypertension who were initially free of cancer and used the following antihypertensive drug classes: Angiotensin-converting enzyme inhibitors (ACEIs); angiotensin receptor blockers (ARBs); beta blockers (BBs); calcium channel blockers (CCBs); and diuretics. During a median follow-up of 8.6 years, there were 4513 (6.4%) overall cancer incidences from an initial 70,549 individuals taking antihypertensive drugs. ARB use was associated with a decreased risk for overall cancer in a crude model (hazard ratio (HR): 0.744, 95% confidence interval (CI): 0.696-0.794) and a fully adjusted model (HR: 0.833, 95% CI: 0.775-0.896) compared with individuals not taking ARBs. Other antihypertensive drugs, including ACEIs, CCBs, BBs, and diuretics, did not show significant associations with incident cancer overall. The long-term use of ARBs was significantly associated with a reduced risk of incident cancer over time. The users of common antihypertensive medications were not associated with an increased risk of cancer overall compared to users of other classes of antihypertensive drugs. ARB use was independently associated with a decreased risk of cancer overall compared to other antihypertensive drugs.
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DOI
10.3390/jcm10040771
Appears in Collections:
의과대학 > 의학과 > Journal papers
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