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IgA Levels Are Associated with Coronary Artery Lesions in Kawasaki Disease

Title
IgA Levels Are Associated with Coronary Artery Lesions in Kawasaki Disease
Authors
Kim, Jae-JungKim, Hea-JiYu, Jeong JinYun, Sin WeonLee, Kyung-YilYoon, Kyung LimKil, Hong-RyangKim, Gi BeomHan, Myung-KiSong, Min SeobLee, Hyoung DooJun, Hyun OkHa, Kee SooHong, Young MiJang, Gi YoungLee, Jong-KeukKorean Kawasaki Dis Genetics Conso
Ewha Authors
홍영미
SCOPUS Author ID
홍영미scopus
Issue Date
2021
Journal Title
KOREAN CIRCULATION JOURNAL
ISSN
1738-5520JCR Link

1738-5555JCR Link
Citation
KOREAN CIRCULATION JOURNAL vol. 51, no. 3, pp. 267 - 278
Keywords
Mucocutaneous lymph node syndromeIgACoronary aneurysms
Publisher
KOREAN SOC CARDIOLOGY
Indexed
SCIE; SCOPUS; KCI WOS
Document Type
Article
Abstract
Background and Objectives: Kawasaki disease (KD) is an acute systemic vasculitis that affects the coronary arteries. Abnormal immune reactions are thought to contribute to disease pathogenesis. The effect of immunoglobulin (Ig) isotype (IgG, IgA, IgM, and IgE) on inflammatory data and clinical outcomes of patients with KD was examined. Methods: Ig levels in 241 patients with KD were measured during the acute, subacute, convalescent, and normal phases of the disease. Results: Compared with reference Ig values, IgG, IgA, and IgM levels were significantly higher in the subacute phase, while IgE levels were elevated in 73.9% (178/241) of patients with KD in all clinical phases. However, high IgE levels were not associated with clinical outcomes, including intravenous immunoglobulin unresponsiveness and coronary artery lesions (CALs). Significantly more CALs were observed in the high IgA group than in the normal IgA group (44.7% vs. 20.8%, respectively; p<0.01). In addition, IgA levels in the acute phase (p=0.038) were 2.2-fold higher, and those in the subacute phase were 1.7-fold higher (p<0.001), in the CAL group than in the non-CAL group. IgA concentrations increased along with the size of the coronary artery aneurysm (p<0.001). Furthermore, there was a strong correlation between IgA levels and CAL size (r=0.435, p<0.001), with a high odds ratio of 2.58 (p=0.022). Conclusions: High IgA levels in patients with KD are prognostic for the risk of CALs.
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DOI
10.4070/kcj.2020.0345
Appears in Collections:
의과대학 > 의학과 > Journal papers
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