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Prospects of Marine Sterols against Pathobiology of Alzheimer's Disease: Pharmacological Insights and Technological Advances

Title
Prospects of Marine Sterols against Pathobiology of Alzheimer's Disease: Pharmacological Insights and Technological Advances
Authors
Rahman M.A.Dash R.Sohag A.A.M.Alam M.Rhim H.Ha H.Moon I.S.Uddin M.J.Hannan M.A.
Ewha Authors
하헌주Md Jamal Uddin
SCOPUS Author ID
하헌주scopus; Md Jamal Uddinscopus
Issue Date
2021
Journal Title
Marine drugs
ISSN
1660-3397JCR Link
Citation
Marine drugs vol. 19, no. 3
Keywords
cholesterol homeostasisfucosterolinflammationmarine steroidsneurodegenerationoxidative stress
Publisher
NLM (Medline)
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Review
Abstract
Alzheimer's disease (AD) is a degenerative brain disorder characterized by a progressive decline in memory and cognition, mostly affecting the elderly. Numerous functional bioactives have been reported in marine organisms, and anti-Alzheimer's agents derived from marine resources have gained attention as a promising approach to treat AD pathogenesis. Marine sterols have been investigated for several health benefits, including anti-cancer, anti-obesity, anti-diabetes, anti-aging, and anti-Alzheimer's activities, owing to their anti-inflammatory and antioxidant properties. Marine sterols interact with various proteins and enzymes participating via diverse cellular systems such as apoptosis, the antioxidant defense system, immune response, and cholesterol homeostasis. Here, we briefly overview the potential of marine sterols against the pathology of AD and provide an insight into their pharmacological mechanisms. We also highlight technological advances that may lead to the potential application of marine sterols in the prevention and therapy of AD.
DOI
10.3390/md19030167
Appears in Collections:
약학대학 > 약학과 > Journal papers
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