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Components of metabolic syndrome and their relation to the risk of incident cerebral infarction

Title
Components of metabolic syndrome and their relation to the risk of incident cerebral infarction
Authors
Park, Sung KeunJung, Ju YoungOh, Chang-MoChoi, Joong-MyungKim, Min-HoHa, EunheeKim, YejiRyoo, Jae-Hong
Ewha Authors
하은희
SCOPUS Author ID
하은희scopus
Issue Date
2021
Journal Title
ENDOCRINE JOURNAL
ISSN
0918-8959JCR Link

1348-4540JCR Link
Citation
ENDOCRINE JOURNAL vol. 68, no. 3, pp. 253 - 259
Keywords
Metabolic syndromeImpaired fasting glucoseElevated blood pressureCerebral infarction
Publisher
JAPAN ENDOCRINE SOC
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Metabolic syndrome (MetS) consists of 5 metabolic components, which are recognized as risk factors for cerebral infarction. The present study was to evaluate the relative influence of individual metabolic component on incident cerebral infarction. Using a data of 209,339 Koreans registered in National Health Information Corporation, we evaluated the risk for incident cerebral infarction according to the number of metabolic component and each metabolic component for 4.37 years? follow-up. Cox proportional hazards model was used to calculate hazard ratios (HRs) for cerebral infarction and their confidence interval (CI). The more metabolic components accompanied the worse metabolic profile, leading increased incidence of cerebral infarction. The risk of cerebral infarction increased proportionally to the number of present metabolic components (number 0: reference, number 1: 1.78 [1.42?2.23], number 2: 2.20 [1.76?2.74], number 3: 2.61 [2.09?3.25] and number 4?5: 3.18 [2.54?3.98]). Compared to subjects without metabolic component, the impact of each component on cerebral infarction was relatively higher in elevated fasting glucose (1.56 [1.14?2.13]) and elevated BP (2.13 [1.66?2.73]), indicating no statistical significance in low HDL-cholesterol (1.53 [0.96?2.44]), high triglyceride (1.24 [0.84?1.84]) and abdominal obesity (1.05 [0.63?1.73]). Proportional relationship was found between the number of metabolic component and risk of cerebral infarction. Out of metabolic components, fasting glucose and BP are more powerful predictor for cerebral infarction. ABSTRACT Metabolic syndrome (MetS) consists of 5 metabolic components, which are recognized as risk factors for cerebral infarction. The present study was to evaluate the relative influence of individual metabolic component on incident cerebral infarction. Using a data of 209,339 Koreans registered in National Health Information Corporation, we evaluated the risk for incident cerebral infarction according to the number of metabolic component and each metabolic component for 4.37 years? follow-up. Cox proportional hazards model was used to calculate hazard ratios (HRs) for cerebral infarction and their confidence interval (CI). The more metabolic components accompanied the worse metabolic profile, leading increased incidence of cerebral infarction. The risk of cerebral infarction increased proportionally to the number of present metabolic components (number 0: reference, number 1: 1.78 [1.42?2.23], number 2: 2.20 [1.76?2.74], number 3: 2.61 [2.09?3.25] and number 4?5: 3.18 [2.54?3.98]). Compared to subjects without metabolic component, the impact of each component on cerebral infarction was relatively higher in elevated fasting glucose (1.56 [1.14?2.13]) and elevated BP (2.13 [1.66?2.73]), indicating no statistical significance in low HDL-cholesterol (1.53 [0.96?2.44]), high triglyceride (1.24 [0.84?1.84]) and abdominal obesity (1.05 [0.63?1.73]). Proportional relationship was found between the number of metabolic component and risk of cerebral infarction. Out of metabolic components, fasting glucose and BP are more powerful predictor for cerebral
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