Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정병문 | * |
dc.date.accessioned | 2021-06-07T16:31:31Z | - |
dc.date.available | 2021-06-07T16:31:31Z | - |
dc.date.issued | 2021 | * |
dc.identifier.issn | 2073-4360 | * |
dc.identifier.other | OAK-29352 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/257638 | - |
dc.description.abstract | Cancer progression and migration in the tumor microenvironment are related to cell types and three-dimensional (3D) matrices. Therefore, developing biomimetic tumor models, including co-culture systems and a tunable 3D matrix, could play an essential role in understanding the cancer environment. Here, multicellular spheroids using human adipose-derived mesenchymal stem cells (hADSCs) and breast cancer cells (MDA-MB-231) within the 3D matrix were used as a tumor microenvironment (TME) mimicking platform. The amphiphilic peptide block copolymer and hyaluronic acid (HA) formed a self-assembled structure, which provides a biocompatible 3D environment for the cells. Multicellular spheroids were formed on the optimized plate and were observed as cell migration from a spheroid within a 3D matrix, such as the invasive and metastatic cancer of TME. This study suggests a new 3D platform using polymer complexes and the importance of tumor complexities, including various cell types and microenvironments. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | * |
dc.description.sponsorship | Jeong, B.; Department of Chemistry and Nanoscience, South Korea; email: bjeong@ewha.ac.kr Park, M.H.; Center for Convergence Bioceramic Materials, South Korea; email: conomo0850@gmail.com | * |
dc.language | English | * |
dc.publisher | MDPI AG | * |
dc.subject | 3D matrix | * |
dc.subject | Migration | * |
dc.subject | Multicellular spheroid | * |
dc.subject | Polymer complex | * |
dc.subject | Tumor microenvironment | * |
dc.title | Poly(Ethylene glycol)-poly(l-alanine)/hyaluronic acid complex as a 3d platform for understanding cancer cell migration in the tumor microenvironment | * |
dc.type | Article | * |
dc.relation.issue | 7 | * |
dc.relation.volume | 13 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | Polymers | * |
dc.identifier.doi | 10.3390/polym13071042 | * |
dc.identifier.wosid | WOS:000638770200001 | * |
dc.identifier.scopusid | 2-s2.0-85103982020 | * |
dc.author.google | Sim J. | * |
dc.author.google | Lee H.J. | * |
dc.author.google | Jeong B. | * |
dc.author.google | Park M.H. | * |
dc.contributor.scopusid | 정병문(7102237959) | * |
dc.date.modifydate | 20240118155902 | * |