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dc.contributor.author한수정-
dc.date.accessioned2021-06-07T16:31:26Z-
dc.date.available2021-06-07T16:31:26Z-
dc.date.issued2021-
dc.identifier.issn1471-2202-
dc.identifier.otherOAK-29367-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/257623-
dc.description.abstractBackground: Balance impairment and lack of postural orientation are serious problems in patients with repetitive mild traumatic brain injury (mTBI). Objective: To investigate whether anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) can improve balance control and gait in repetitive mTBI rat models. Methods: In this prospective animal study, 65 repetitive mTBI rats were randomly assigned to two groups: the tDCS group and the control group. To create repetitive mTBI model rats, we induced mTBI in the rats for 3 consecutive days. The tDCS group received one session of anodal tDCS over the M1 area 24 h after the third induced mTBI, while the control group did not receive tDCS treatment. Motor-evoked potential (MEP), foot-fault test, and rotarod test were evaluated before mTBI, before tDCS and after tDCS. The Mann–Whitney U test and Wilcoxon signed rank test were used to assess the effects of variables between the two groups. Results: Anodal tDCS over the M1 area significantly improved the amplitude of MEP in the tDCS group (p = 0.041). In addition, rotarod duration was significantly increased in the tDCS group (p = 0.001). The foot-fault ratio was slightly lower in the tDCS group, however, this was not statistically significant. Conclusion: Anodal tDCS at the M1 area could significantly improve the amplitude of MEP and balance function in a repetitive mTBI rat model. We expect that anodal tDCS would have the potential to improve balance in patients with repetitive mTBI. © 2021, The Author(s).-
dc.languageEnglish-
dc.publisherBioMed Central Ltd-
dc.subjectBalance-
dc.subjectMild traumatic brain injury-
dc.subjectMotor evoked potential-
dc.subjectTDCS-
dc.titleTranscranial direct current stimulation for balance and gait in repetitive mild traumatic brain injury in rats-
dc.typeArticle-
dc.relation.issue1-
dc.relation.volume22-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.journaltitleBMC Neuroscience-
dc.identifier.doi10.1186/s12868-021-00633-4-
dc.identifier.wosidWOS:000640845500001-
dc.identifier.scopusid2-s2.0-85104401509-
dc.author.googlePark G.-
dc.author.googleSuh J.H.-
dc.author.googleHan S.J.-
dc.contributor.scopusid한수정(57217617482;25937300200)-
dc.date.modifydate20210915113033-
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의과대학 > 의학과 > Journal papers
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