Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 남상집 | * |
dc.date.accessioned | 2021-06-07T16:31:21Z | - |
dc.date.available | 2021-06-07T16:31:21Z | - |
dc.date.issued | 2021 | * |
dc.identifier.issn | 1660-3397 | * |
dc.identifier.other | OAK-29380 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/257611 | - |
dc.description.abstract | Two new secondary metabolites, svalbamides A (1) and B (2), were isolated from a culture extract of Paenibacillus sp. SVB7 that was isolated from surface sediment from a core (HH17-1085) taken in the Svalbard archipelago in the Arctic Ocean. The combinational analysis of HR-MS and NMR spectroscopic data revealed the structures of 1 and 2 as being lipopeptides bearing 3-amino-2-pyrrolidinone, D-valine, and 3-hydroxy-8-methyldecanoic acid. The absolute configurations of the amino acid residues in svalbamides A and B were determined using the advanced Marfey’s method, in which the hydrolysates of 1 and 2 were derivatized with L-and D-forms of 1-fluoro-2,4-dinitrophenyl-5-alanine amide (FDAA). The absolute configurations of 1 and 2 were completely assigned by deducing the stereochemistry of 3-hydroxy-8-methyldecanoic acid based on DP4 calcu-lations. Svalbamides A and B induced quinone reductase activity in Hepa1c1c7 murine hepatoma cells, indicating that they represent chemotypes with a potential for functioning as chemopreventive agents. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | * |
dc.description.sponsorship | Oh, D.-C.; Natural Products Research Institute, South Korea; email: dongchanoh@snu.ac.kr | * |
dc.language | English | * |
dc.publisher | MDPI AG | * |
dc.subject | 3-amino-2-pyrrolidinone | * |
dc.subject | Arctic | * |
dc.subject | DP4 calculation | * |
dc.subject | Lipopeptide | * |
dc.subject | Marfey’s method | * |
dc.subject | Paenibacillus | * |
dc.subject | Quinone reductase | * |
dc.subject | Svalbard | * |
dc.title | Svalbamides A and B, pyrrolidinone-bearing lipodipeptides from arctic paenibacillus sp. | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 19 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | Marine Drugs | * |
dc.identifier.doi | 10.3390/MD19040229 | * |
dc.identifier.wosid | WOS:000643209600001 | * |
dc.identifier.scopusid | 2-s2.0-85105237700 | * |
dc.author.google | Du Y.E. | * |
dc.author.google | Bae E.S. | * |
dc.author.google | Lim Y. | * |
dc.author.google | Cho J.-C. | * |
dc.author.google | Nam S.-J. | * |
dc.author.google | Shin J. | * |
dc.author.google | Lee S.K. | * |
dc.author.google | Nam S.-I. | * |
dc.author.google | Oh D.-C. | * |
dc.contributor.scopusid | 남상집(57208839798) | * |
dc.date.modifydate | 20240220120010 | * |