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Pgc1α loss promotes lung cancer metastasis through epithelial-mesenchymal transition

Title
Pgc1α loss promotes lung cancer metastasis through epithelial-mesenchymal transition
Authors
Oh T.-I.Lee M.Lee Y.-M.Kim G.-H.Lee D.You J.S.Kim S.H.Choi M.Jang H.Park Y.-M.Shin H.-W.Shin D.H.Lim J.-H.
Ewha Authors
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SCOPUS Author ID
이대기scopus
Issue Date
2021
Journal Title
Cancers
ISSN
2072-6694JCR Link
Citation
Cancers vol. 13, no. 8
Keywords
EMTID1Lung cancerMetastasisPGC1αTCF4TWIST1
Publisher
MDPI AG
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
PGC1α oppositely regulates cancer metastasis in melanoma, breast, and pancreatic cancer; however, little is known about its impact on lung cancer metastasis. Transcriptome and in vivo xenograft analysis show that a decreased PGC1α correlates with the epithelial–mesenchymal transition (EMT) and lung cancer metastasis. The deletion of a single Pgc1α allele in mice promotes bone metastasis of KrasG12D-driven lung cancer. Mechanistically, PGC1α predominantly activates ID1 expression, which interferes with TCF4-TWIST1 cooperation during EMT. Bioinformatic and clinical studies have shown that PGC1α and ID1 are downregulated in lung cancer, and correlate with a poor survival rate. Our study indicates that TCF4-TWIST1-mediated EMT, which is regulated by the PGC1α-ID1 transcriptional axis, is a potential diagnostic and therapeutic target for metastatic lung cancer. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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DOI
10.3390/cancers13081772
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자연과학대학 > 생명과학전공 > Journal papers
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