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Eudesmane and Eremophilane Sesquiterpenes from the Fruits of Alpinia oxyphylla with Protective Effects against Oxidative Stress in Adipose-Derived Mesenchymal Stem Cells
- Eudesmane and Eremophilane Sesquiterpenes from the Fruits of Alpinia oxyphylla with Protective Effects against Oxidative Stress in Adipose-Derived Mesenchymal Stem Cells
- Thapa, Punam; Lee, Yoo Jin; Tiep Tien Nguyen; Piao, Donglan; Lee, Hwaryeong; Han, Sujin; Lee, Yeon Jin; Han, Ah-Reum; Choi, Hyukjae; Jeong, Jee-Heon; Nam, Joo-Won; Seo, Eun Kyoung
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- MOLECULES vol. 26, no. 6
- Alpinia oxyphylla; eudesmane sesquiterpene; eremophilane sesquiterpene; adipose-derived mesenchymal stem cell; antioxidant; oxidative stress
- SCIE; SCOPUS
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- Alpinia oxyphylla Miquel (Zingiberaceae) has been reported to show antioxidant, anti-inflammatory, and neuroprotective effects. In this study, two new eudesmane sesquiterpenes, 7 alpha-hydroperoxy eudesma-3,11-diene-2-one (1) and 7 beta-hydroperoxy eudesma-3,11-diene-2-one (2), and a new eremophilane sesquiterpene, 3 alpha-hydroxynootkatone (3), were isolated from the MeOH extract of dried fruits of A. oxyphylla along with eleven known sesquiterpenes (4-14). The structures were elucidated by the analysis of 1D/2D NMR, high-resolution electrospray ionization mass spectrometry (HRESIMS), and optical rotation data. Compounds (1-3, 5-14) were evaluated for their protective effects against tert-butyl hydroperoxide (tBHP)-induced oxidative stress in adipose-derived mesenchymal stem cells (ADMSCs). As a result, treatment with isolated compounds, especially compounds 11 and 12, effectively reverted the damage of tBHP on ADMSCs in a dose-dependent manner. In particular, 11 and 12 at 50 mu M improved the viability of tBHP-toxified ADMSCs by 1.69 +/- 0.05-fold and 1.61 +/- 0.03-fold, respectively.
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