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Eudesmane and Eremophilane Sesquiterpenes from the Fruits of Alpinia oxyphylla with Protective Effects against Oxidative Stress in Adipose-Derived Mesenchymal Stem Cells

Title
Eudesmane and Eremophilane Sesquiterpenes from the Fruits of Alpinia oxyphylla with Protective Effects against Oxidative Stress in Adipose-Derived Mesenchymal Stem Cells
Authors
Thapa, PunamLee, Yoo JinTiep Tien NguyenPiao, DonglanLee, HwaryeongHan, SujinLee, Yeon JinHan, Ah-ReumChoi, HyukjaeJeong, Jee-HeonNam, Joo-WonSeo, Eun Kyoung
Ewha Authors
서은경
SCOPUS Author ID
서은경scopus
Issue Date
2021
Journal Title
MOLECULES
ISSN
1420-3049JCR Link
Citation
MOLECULES vol. 26, no. 6
Keywords
Alpinia oxyphyllaeudesmane sesquiterpeneeremophilane sesquiterpeneadipose-derived mesenchymal stem cellantioxidantoxidative stress
Publisher
MDPI
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
Alpinia oxyphylla Miquel (Zingiberaceae) has been reported to show antioxidant, anti-inflammatory, and neuroprotective effects. In this study, two new eudesmane sesquiterpenes, 7 alpha-hydroperoxy eudesma-3,11-diene-2-one (1) and 7 beta-hydroperoxy eudesma-3,11-diene-2-one (2), and a new eremophilane sesquiterpene, 3 alpha-hydroxynootkatone (3), were isolated from the MeOH extract of dried fruits of A. oxyphylla along with eleven known sesquiterpenes (4-14). The structures were elucidated by the analysis of 1D/2D NMR, high-resolution electrospray ionization mass spectrometry (HRESIMS), and optical rotation data. Compounds (1-3, 5-14) were evaluated for their protective effects against tert-butyl hydroperoxide (tBHP)-induced oxidative stress in adipose-derived mesenchymal stem cells (ADMSCs). As a result, treatment with isolated compounds, especially compounds 11 and 12, effectively reverted the damage of tBHP on ADMSCs in a dose-dependent manner. In particular, 11 and 12 at 50 mu M improved the viability of tBHP-toxified ADMSCs by 1.69 +/- 0.05-fold and 1.61 +/- 0.03-fold, respectively.
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DOI
10.3390/molecules26061762
Appears in Collections:
약학대학 > 약학과 > Journal papers
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