View : 99 Download: 0

Comparison of oncologic outcomes between transduodenal ampullectomy and pancreatoduodenectomy in ampulla of vater cancer: Korean multicenter study

Title
Comparison of oncologic outcomes between transduodenal ampullectomy and pancreatoduodenectomy in ampulla of vater cancer: Korean multicenter study
Authors
Hong S.-S.Han S.-S.Kwon W.Jang J.-Y.Kim H.-J.Cho C.-K.Ahn K.-S.Yang J.-D.Park Y.Min S.-K.Moon J.-I.Roh Y.-H.Lee S.-E.Park J.-S.Kim S.-G.Jeong C.-Y.Heo J.-S.Hwang H.-K.
Ewha Authors
민석기
SCOPUS Author ID
민석기scopus
Issue Date
2021
Journal Title
Cancers
ISSN
2072-6694JCR Link
Citation
Cancers vol. 13, no. 9
Keywords
Ampulla of Vater cancerPancreaticoduodenectomyTransduodenal ampullectomy
Publisher
MDPI AG
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
This study used multicenter data to compare the oncological safety of transduodenal ampullectomy (TDA) with that of pylorus-preserving pancreatoduodenectomy (PPPD) in early ampulla of Vater (AoV) cancer. Data for patients who underwent surgical resection for AoV cancer (pTis–T2 stage) from January 2000 to September 2019 were collected from 15 institutions. The clinicopathologic characteristics and survival outcomes were compared between the PPPD and TDA groups. A total of 486 patients were enrolled (PPPD, 418; TDA, 68). The oncologic behavior in the PPPD group was more aggressive than that in the TDA group at all T stages: larger tumor size (p = 0.034), advanced T stage (p < 0.001), aggressive cell differentiation (p < 0.001), and more lymphovascular invasion (p = 0.002). Five-year disease-free survival (DFS) and overall survival (OS) did not differ between the two groups when considering all T stages or only the Tis+T1 group. Among T1 patients, PPPD produced significantly better DFS (PPPD vs. TDA, 84.8% vs. 66.6%, p = 0.040) and superior OS (PPPD vs. TDA, 89.1% vs. 68.0%, p = 0.056) than TDA. Lymph node dissection (LND) in the TDA group did not affect DFS or OS (TDA + LND vs. TDA-only, DFS, p = 0.784; OS, p = 0.870). In conclusion, PPPD should be the standard procedure for early AoV cancer. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Show the fulltext
DOI
10.3390/cancers13092038
Appears in Collections:
의과대학 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE