View : 54 Download: 0

The Multifaceted Roles of USP15 in Signal Transduction

Title
The Multifaceted Roles of USP15 in Signal Transduction
Authors
Das T.Song E.J.Kim E.E.
Ewha Authors
송은주
SCOPUS Author ID
송은주scopus
Issue Date
2021
Journal Title
International journal of molecular sciences
ISSN
1422-0067JCR Link
Citation
International journal of molecular sciences vol. 22, no. 9
Keywords
BMPCSNIGFNF-κBNrf2–Keap1p53RNA splicingTGF-βUSP15Wnt/β-catenin
Publisher
NLM (Medline)
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Review
Abstract
Ubiquitination and deubiquitination are protein post-translational modification processes that have been recognized as crucial mediators of many complex cellular networks, including maintaining ubiquitin homeostasis, controlling protein stability, and regulating several signaling pathways. Therefore, some of the enzymes involved in ubiquitination and deubiquitination, particularly E3 ligases and deubiquitinases, have attracted attention for drug discovery. Here, we review recent findings on USP15, one of the deubiquitinases, which regulates diverse signaling pathways by deubiquitinating vital target proteins. Even though several basic previous studies have uncovered the versatile roles of USP15 in different signaling networks, those have not yet been systematically and specifically reviewed, which can provide important information about possible disease markers and clinical applications. This review will provide a comprehensive overview of our current understanding of the regulatory mechanisms of USP15 on different signaling pathways for which dynamic reverse ubiquitination is a key regulator.
Show the fulltext
DOI
10.3390/ijms22094728
Appears in Collections:
약학대학 > 약학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE