Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김우성 | * |
dc.date.accessioned | 2021-06-07T16:30:57Z | - |
dc.date.available | 2021-06-07T16:30:57Z | - |
dc.date.issued | 2021 | * |
dc.identifier.issn | 1663-9812 | * |
dc.identifier.other | OAK-29449 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/257546 | - |
dc.description.abstract | Staphylococcus aureus and Candida spp. are commonly linked with topical biofilm-associated infections such as those found on chronic wounds. These biofilms are notoriously difficult to treat, highlighting the grave need to discover and study new broad-spectrum agents to combat associated infections. Here we report that the kinase inhibitor Bay 11-7085 exhibited bactericidal activity against multidrug-resistant S. aureus with a minimum inhibitory concentration (MIC) of 4 μg/ml. In addition, S. aureus strain MW2 did not acquire resistance to antibiotic pressure. Furthermore, Bay 11-7085 exhibited potency against Candida albicans and the emerging pathogen Candida auris with a MIC of 0.5–1 μg/ml. Bay 11-7085 partially inhibited and eradicated biofilm formation of various pathogens, such as VRSA (vancomycin-resistant S. aureus), as well as antifungal-resistant Candida spp. isolates. Notably, Bay 11-7085 partially inhibited initial cell attachment and formation of a VRSA-C. albicans polymicrobial biofilm in vitro. In contrast to C. albicans, inhibition of VRSA biofilm was linked to initial cell attachment independent of its bactericidal activity. Finally, Bay 11-7085 was effective in vivo at increasing the lifespan of C. elegans during an S. aureus and a C. albicans infection. Our work proposes kinase inhibitor Bay 11-7085 as a potential compound capable of combating biofilms associated with primary multidrug-resistant bacteria and yeast pathogens associated with wound infections. © Copyright © 2021 Escobar, Possamai Rossatto, Kim, Kang, Kim and Mylonakis. | * |
dc.language | English | * |
dc.publisher | Frontiers Media S.A. | * |
dc.subject | antibiotic resistance | * |
dc.subject | Bay 11-7085 | * |
dc.subject | biofilms | * |
dc.subject | C. elegans high through-put screening | * |
dc.subject | Candida albicans | * |
dc.subject | Staphylococcus aureus | * |
dc.title | Repurposing Kinase Inhibitor Bay 11-7085 to Combat Staphylococcus aureus and Candida albicans Biofilms | * |
dc.type | Article | * |
dc.relation.volume | 12 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | Frontiers in Pharmacology | * |
dc.identifier.doi | 10.3389/fphar.2021.675300 | * |
dc.identifier.wosid | WOS:000651758300001 | * |
dc.identifier.scopusid | 2-s2.0-85105977436 | * |
dc.author.google | Escobar I.E. | * |
dc.author.google | Possamai Rossatto F.C. | * |
dc.author.google | Kim S.M. | * |
dc.author.google | Kang M.H. | * |
dc.author.google | Kim W. | * |
dc.author.google | Mylonakis E. | * |
dc.contributor.scopusid | 김우성(57201881427) | * |
dc.date.modifydate | 20240308142800 | * |