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Phytochemicals as a Complement to Cancer Chemotherapy: Pharmacological Modulation of the Autophagy-Apoptosis Pathway

Title
Phytochemicals as a Complement to Cancer Chemotherapy: Pharmacological Modulation of the Autophagy-Apoptosis Pathway
Authors
Rahman M.A.Hannan M.A.Dash R.Rahman M.D.H.Islam R.Uddin M.J.Sohag A.A.M.Rahman M.H.Rhim H.
Ewha Authors
Md Jamal Uddin
SCOPUS Author ID
Md Jamal Uddinscopus
Issue Date
2021
Journal Title
Frontiers in Pharmacology
ISSN
1663-9812JCR Link
Citation
Frontiers in Pharmacology vol. 12
Keywords
anticancerapoptosisautophagypharmacologyphytochemicals
Publisher
Frontiers Media S.A.
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Review
Abstract
Bioactive plant derived compounds are important for a wide range of therapeutic applications, and some display promising anticancer properties. Further evidence suggests that phytochemicals modulate autophagy and apoptosis, the two crucial cellular pathways involved in the underlying pathobiology of cancer development and regulation. Pharmacological targeting of autophagy and apoptosis signaling using phytochemicals therefore offers a promising strategy that is complementary to conventional cancer chemotherapy. In this review, we sought to highlight the molecular basis of the autophagic-apoptotic pathway to understand its implication in the pathobiology of cancer, and explore this fundamental cellular process as a druggable anticancer target. We also aimed to present recent advances and address the limitations faced in the therapeutic development of phytochemical-based anticancer drugs. © Copyright © 2021 Rahman, Hannan, Dash, Rahman, Islam, Uddin, Sohag, Rahman and Rhim.
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DOI
10.3389/fphar.2021.639628
Appears in Collections:
연구기관 > 약학연구소 > Journal papers
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