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Risk of Absence of Measles Antibody in Healthcare Personnel and Efficacy of Booster Vaccination

Title
Risk of Absence of Measles Antibody in Healthcare Personnel and Efficacy of Booster Vaccination
Authors
Kim, Chung-JongBae, Ji-YunJun, Kang-IlChung, Hae-SunKim, AeyeonKim, JiheeSon, Hee-JungLee, MiaeChoi, Hee-Jung
Ewha Authors
이미애최희정정혜선김충종배지윤
SCOPUS Author ID
이미애scopus; 최희정scopus; 정혜선scopus; 김충종scopus
Issue Date
2021
Journal Title
VACCINES
ISSN
2076-393XJCR Link
Citation
VACCINES vol. 9, no. 5
Keywords
measleshealth personnelvaccination
Publisher
MDPI
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
We aimed to identify the presence of the measles IgG antibody (mIgG-Ab) in healthcare personnel and finding out who needs the measles vaccination. The history of measles vaccination was obtained from the national vaccine registry. A baseline mIgG-Ab test was performed, and the measles vaccine was administered to participants who tested negative or equivocal for mIgG-Abs. During the study, 2885 (87.3%) of the 3303 employees were tested for measles serostatus. The baseline seropositivity rate for mIgG-Abs was 91.9%. Among the 234 seronegative cases, 82.9% were born after 1985. The seroprevalence rate was lower in those who received the measles-mumps-rubella (MMR) vaccine >10 years before the testing time, especially if they were born after 1985 and if there was only one previous record of vaccination. Among the 234 seronegative cases, MMR vaccination was administered in 174 cases, of which serostatus was evaluated in 146 cases. After the first dose, positive seroconversion was achieved in 126 participants (86.3%). After a second dose, 15 achieved (75.0%) positive seroconversion. In healthcare personnel born after the period when measles incidence significantly decreased, it may be necessary to reassess their immune status for measles if more than 10 years have elapsed since the last vaccination.
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DOI
10.3390/vaccines9050501
Appears in Collections:
의과대학 > 의학과 > Journal papers
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