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Revisiting pharmacological potentials of Nigella sativa seed: A promising option for COVID-19 prevention and cure

Title
Revisiting pharmacological potentials of Nigella sativa seed: A promising option for COVID-19 prevention and cure
Authors
Islam M.N.Hossain K.S.Sarker P.P.Ferdous J.Hannan M.A.Rahman M.M.Chu D.-T.Uddin M.J.
Ewha Authors
Md Jamal Uddin
SCOPUS Author ID
Md Jamal Uddinscopus
Issue Date
2021
Journal Title
Phytotherapy Research
ISSN
0951-418XJCR Link
Citation
Phytotherapy Research vol. 35, no. 3, pp. 1329 - 1344
Keywords
autophagyCOVID-19immune responseinflammationNigella sativaoxidative stressSARS-CoV-2 infection
Publisher
John Wiley and Sons Ltd
Indexed
SCIE; SCOPUS scopus
Document Type
Review
Abstract
Nigella sativa seed and its active compounds have been historically recognized as an effective herbal panacea that can establish a balanced inflammatory response by suppressing chronic inflammation and promoting healthy immune response. The essential oil and other preparations of N. sativa seed have substantial therapeutic outcomes against immune disturbance, autophagy dysfunction, oxidative stress, ischemia, inflammation, in several COVID-19 comorbidities such as diabetes, cardiovascular disorders, Kawasaki-like diseases, and many bacterial and viral infections. Compelling evidence in the therapeutic efficiency of N. sativa along with the recent computational findings is strongly suggestive of combating emerged COVID-19 pandemic. Also, being an available candidate in nutraceuticals, N. sativa seed oil could be immensely potential and feasible to prevent and cure COVID-19. This review was aimed at revisiting the pharmacological benefits of N. sativa seed and its active metabolites that may constitute a potential basis for developing a novel preventive and therapeutic strategy against COVID-19. Bioactive compounds of N. sativa seed, especially thymiquinone, α-hederin, and nigellidine, could be alternative and promising herbal drugs to combat COVID-19. Preclinical and clinical trials are required to delineate detailed mechanism of N. sativa's active components and to investigate their efficacy and potency under specific pathophysiological conditions of COVID-19. © 2020 John Wiley & Sons Ltd
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DOI
10.1002/ptr.6895
Appears in Collections:
연구기관 > 약학연구소 > Journal papers
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