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Recent progress in development and applications of second near-infrared (NIR-II) nanoprobes

Title
Recent progress in development and applications of second near-infrared (NIR-II) nanoprobes
Authors
Shinn, JongyoonLee, SunyoungLee, Hyon KyongAhn, JaeeunLee, Seon AhLee, SeonjuLee, Yonghyun
Ewha Authors
이용현
SCOPUS Author ID
이용현scopus
Issue Date
2021
Journal Title
ARCHIVES OF PHARMACAL RESEARCH
ISSN
0253-6269JCR Link

1976-3786JCR Link
Citation
ARCHIVES OF PHARMACAL RESEARCH vol. 44, no. 2, pp. 165 - 181
Keywords
NIR-II nanoprobesPhotothermal therapyPhotodynamic therapyPhotoacoustic ImagingFluorescence Imaging
Publisher
PHARMACEUTICAL SOC KOREA
Indexed
SCIE; SCOPUS; KCI WOS scopus
Document Type
Review
Abstract
Optical probes for near-infrared (NIR) light have clear advantages over UV/VIS-based optical probes, such as their low levels of interfering auto-fluorescence and high tissue penetration. The second NIR (NIR-II) window (1000-1350 nm) offers better light penetration, lower background signal, higher safety limit, and higher maximum permitted exposure than the first NIR (NIR-I) window (650-950 nm). Therefore, NIR-II laser-based photoacoustic (PA) and fluorescence (FL) imaging can offer higher sensitivity and penetration depth than was previously available, and deeper lesions can be treated in vivo by photothermal therapy (PTT) and photodynamic therapy (PDT) with an NIR-II laser than with an NIR-I laser. Advances in creation of novel nanomaterials have increased options for improving light-induced bioimaging and treatment. Nanotechnology can provide advantages such as good disease targeting ability and relatively long circulation times to supplement the advantages of optical technologies. In this review, we present recent progress in development and applications of NIR-II light-based nanoplatforms for FL, PA, image-guided surgery, PDT, and PTT. We also discuss recent advances in smart NIR-II nanoprobes that can respond to stimuli in the tumor microenvironment and inflamed sites. Finally, we consider the challenges involved in using NIR-II nanomedicine for effective diagnosis and treatment.
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DOI
10.1007/s12272-021-01313-x
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약학대학 > 약학과 > Journal papers
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