View : 32 Download: 0

Comparative differences in the atherosclerotic disease burden between the epicardial coronary arteries: quantitative plaque analysis on coronary computed tomography angiography

Title
Comparative differences in the atherosclerotic disease burden between the epicardial coronary arteries: quantitative plaque analysis on coronary computed tomography angiography
Authors
Bax, A. Maximvan Rosendael, Alexander R.Ma, Xiaoyuevan den Hoogen, Inge J.Gianni, UmbertoTantawy, Sara W.Hollenberg, Emma J.Andreini, DanieleAl-Mallah, Mouaz H.Budoff, Matthew J.Cademartiri, FilippoChinnaiyan, KavithaChoi, Jung HyunConte, EdoardoMarques, HugoGoncalves, Pedro de AraujoGottlieb, IlanHadamitzky, MartinLeipsic, Jonathon A.Maffei, EricaPontone, GianlucaShin, SanghoonKim, Yong-JinLee, Byoung KwonChun, Eun JuSung, Ji MinLee, Sang-EunVirmani, RenuSamady, HabibStone, Peter H.Berman, Daniel S.Min, James K.Narula, JagatLin, Fay Y.Chang, Hyuk-JaeShaw, Leslee J.PARADIGM Investigators
Ewha Authors
신상훈
SCOPUS Author ID
신상훈scopusscopusscopusscopus
Issue Date
2021
Journal Title
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
ISSN
2047-2404JCR Link

2047-2412JCR Link
Citation
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING vol. 22, no. 3, pp. 322 - 330
Keywords
coronary computed tomography angiographycoronary artery diseasecoronary artery plaque composition
Publisher
OXFORD UNIV PRESS
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Aims Anatomic series commonly report the extent and severity of coronary artery disease (CAD), regardless of location. The aim of this study was to evaluate differences in atherosclerotic plaque burden and composition across the major epicardial coronary arteries. Methods and results A total of 1271 patients (age 60 +/- 9 years; 57% men) with suspected CAD prospectively underwent coronary computed tomography angiography (CCTA). Atherosclerotic plaque volume was quantified with categorization by composition (necrotic core, fibrofatty, fibrous, and calcified) based on Hounsfield Unit density. Per-vessel measures were compared using generalized estimating equation models. On CCTA, total plaque volume was lowest in the LCx (10.0 +/- 29.4 mm(3)), followed by the RCA (32.8 +/- 82.7 mm(3); P < 0.001), and LAD (58.6 +/- 83.3 mm(3); P < 0.001), even when correcting for vessel length or volume. The prevalence of >= 2 high-risk plaque features, such as positive remodelling or spotty calcification, occurred less in the LCx (3.8%) when compared with the LAD (21.4%) or RCA (10.9%, P < 0.001). In the LCx, the most stenotic lesion was categorized as largely calcified more often than in the RCA and LAD (55.3% vs. 39.4% vs. 32.7%; P<0.001). Median diameter stenosis was also lowest in the LCx (16.2%) and highest in the LAD (21.3%; P<0.001) and located more distal along the LCx when compared with the RCA and LAD (P < 0.001). Conclusion Atherosclerotic plaque, irrespective of vessel volume, varied across the epicardial coronary arteries; with a significantly lower burden and different compositions in the LCx when compared with the LAD and RCA. These volumetric and compositional findings support a diverse milieu for atherosclerotic plaque development and may contribute to a varied acute coronary risk between the major epicardial coronary arteries. [GRAPHICS] .
Show the fulltext
DOI
10.1093/ehjci/jeaa275
Appears in Collections:
의료원 > 의료원 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE