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Janus Nanosheets with Face-Selective Molecular Recognition Properties from DNA-Peptide Conjugates
- Title
- Janus Nanosheets with Face-Selective Molecular Recognition Properties from DNA-Peptide Conjugates
- Authors
- Albert, Shine K.; Lee, Sunghee; Durai, Prasannavenkatesh; Hu, Xiaole; Jeong, Byeongmoon; Park, Keunwan; Park, So-Jung
- Ewha Authors
- 정병문; 박소정
- SCOPUS Author ID
- 정병문; 박소정
- Issue Date
- 2021
- Journal Title
- SMALL
- ISSN
- 1613-6810
1613-6829
- Citation
- SMALL vol. 17, no. 12
- Keywords
- DNA; Janus; nanosheets; peptides; self‐ assembly
- Publisher
- WILEY-V C H VERLAG GMBH
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Chemical and functional anisotropy in Janus materials offer intriguing possibilities for constructing complex nanostructures and regulating chemical and biological reactions. Here, the authors report the fabrication of Janus nanosheets from molecular building blocks composed of two information-carrying biopolymers, DNA and peptides. Experimental and structural modeling studies reveal that DNA-peptide diblock conjugates assemble into Janus nanosheets with distinct DNA and peptide faces. The surprising level of structural control is attributed to the exclusive parallel beta-sheet formation of phenylalanine-rich peptides. This approach is extended to triblock DNA1-peptide-DNA2 conjugates, which assemble into nanosheets presenting two different DNA on opposite faces. The Janus nanosheets with independently addressable faces are utilized to organize an enzyme pair for concerted enzymatic reactions, where enhanced catalytic activities are observed. These results demonstrate that the predictable and designable peptide interaction is a promising tool for creating Janus nanostructures with regio-selective and sequence-specific molecular recognition properties.
- DOI
- 10.1002/smll.202006110
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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