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Adenovirus Vectors: Excellent Tools for Vaccine Development

Title
Adenovirus Vectors: Excellent Tools for Vaccine Development
Authors
Chang, Jun
Ewha Authors
장준
SCOPUS Author ID
장준scopus
Issue Date
2021
Journal Title
IMMUNE NETWORK
ISSN
1598-2629JCR Link

2092-6685JCR Link
Citation
IMMUNE NETWORK vol. 21, no. 1
Keywords
AdenovirusGenetic vectorAdenovectorVaccine
Publisher
KOREA ASSOC IMMUNOLOGISTS
Indexed
SCIE; SCOPUS; KCI WOS scopus
Document Type
Review
Abstract
Adenovirus was originally used as a vector for gene therapy. In recent years, with the development of the next-generation vectors with increased safety and high immunogenicity to transgene products, its utility as a vaccine vector has continued to increase. Adenovirus-based vaccines are currently being tested not only to prevent various infectious diseases but also to be applied as cancer vaccines. In this review, I discuss the innate and adaptive aspects of the immunological characteristics of adenovirus vectors and further examine the current status of advanced adenovirus-based vaccine development. Various methods that can overcome the limitations of currently used adenoviruses as vaccine vehicles are also discussed. Through this study, I hope that vaccine development using adenovirus vectors will be expedited and more successful.
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DOI
10.4110/in.2021.21.e6
Appears in Collections:
약학대학 > 약학과 > Journal papers
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