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Association of Vitamin D Deficiency with Diabetic Nephropathy

Title
Association of Vitamin D Deficiency with Diabetic Nephropathy
Authors
Hong, So-hyeonKim, Young BinChoi, Hoon SungJeong, Tae-DongKim, Jin TaekSung, Yeon Ah
Ewha Authors
성연아정태동홍소현
SCOPUS Author ID
성연아scopus; 정태동scopus; 홍소현scopus
Issue Date
2021
Journal Title
ENDOCRINOLOGY AND METABOLISM
ISSN
2093-596XJCR Link

2093-5978JCR Link
Citation
ENDOCRINOLOGY AND METABOLISM vol. 36, no. 1, pp. 106 - 113
Keywords
AlbuminuriaDiabetes complicationsDiabetic nephropathiesVitamin D
Publisher
KOREAN ENDOCRINE SOC
Indexed
SCIE; SCOPUS; KCI WOS scopus
Document Type
Article
Abstract
Background: Low 25-hydroxyvitamin D (25OHD) levels are associated with the incidence of type 2 diabetes mellitus (T2DM). However, the association between 25OHD and metabolic health status or diabetic complications is inconclusive. We evaluated this relationship between vitamin D status and metabolic parameters and complications of T2DM. Methods: This study included 1,392 patients with T2DM who visited Eulji and Ewha Diabetes Center between January 2011 and August 2016. Anthropometric parameters and laboratory tests including glycated hemoglobin (HbA1c), lipid profile, liver and kidney function, and urinary albumin-to-creatinine ratio (UACR) were evaluated. Diabetic macro- and microvascular complications were determined through a medical record review. Serum 25OHD concentrations were measured by chemiluminescent immunoassay. Results: The mean 25OHD level was 16.8 +/- 9.6 ng/mL. Vitamin D deficiency (<20 ng/mL) and severe deficiency (< 10 ng/mL) were observed in 990 (71.1%) and 351 (25.2%) participants, respectively. 25OHD level was positively correlated with age and high-density lipoprotein cholesterol (HDL-C) level and negatively correlated with HbA1c, triglyceride level, and UACR. HDL-C and UACR were significantly associated with 25OHD after adjusting for other variables. Vitamin D deficiency was independently related to nephropathy after adjusting for confounding variables. Conclusion: Vitamin D deficiency was common among Korean T2DM patients; it was independently associated with microalbuminuria and HDL level, and positively related to diabetic nephropathy.
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DOI
10.3803/EnM.2020.826
Appears in Collections:
의과대학 > 의학과 > Journal papers
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