DSpace at EWHA: Redox-responsive nanoparticles self-assembled from porphyrin-betulinic acid conjugates for chemo- and photodynamic therapy

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Redox-responsive nanoparticles self-assembled from porphyrin-betulinic acid conjugates for chemo- and photodynamic therapy

Title: Redox-responsive nanoparticles self-assembled from porphyrin-betulinic acid conjugates for chemo- and photodynamic therapy

Authors: Özdemir Z.; Yang M.; Kim G.; Bildziukevich U.; Šaman D.; Li X.; Yoon J.; Wimmer Z.

Keywords: Photodynamic therapy; Redox-responsive; ROS; Self-assembled nanoparticles; Tumour targeting

Abstract: The redox-responsive nanoparticle (NanoP-ss-BA) is designed by linking the porphyrin derivative (P) to the naturally occurring betulinic acid (BA) through a disulphide bond. A GSH triggered disassembly of NanoP-ss-BA effectively promotes a singlet oxygen (1O2) production, but also releases lipophilic anticancer drug, BA in situ. Beside this, high phototoxicity of NanoP-ss-BA serves it as a good candidate for photodynamic therapy (PDT). © 2021 Elsevier Ltd