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Redox-responsive nanoparticles self-assembled from porphyrin-betulinic acid conjugates for chemo- and photodynamic therapy

Title
Redox-responsive nanoparticles self-assembled from porphyrin-betulinic acid conjugates for chemo- and photodynamic therapy
Authors
Özdemir Z.Yang M.Kim G.Bildziukevich U.Šaman D.Li X.Yoon J.Wimmer Z.
Ewha Authors
윤주영
SCOPUS Author ID
윤주영scopus
Issue Date
2021
Journal Title
Dyes and Pigments
ISSN
0143-7208JCR Link
Citation
Dyes and Pigments vol. 190
Keywords
Photodynamic therapyRedox-responsiveROSSelf-assembled nanoparticlesTumour targeting
Publisher
Elsevier Ltd
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
The redox-responsive nanoparticle (NanoP-ss-BA) is designed by linking the porphyrin derivative (P) to the naturally occurring betulinic acid (BA) through a disulphide bond. A GSH triggered disassembly of NanoP-ss-BA effectively promotes a singlet oxygen (1O2) production, but also releases lipophilic anticancer drug, BA in situ. Beside this, high phototoxicity of NanoP-ss-BA serves it as a good candidate for photodynamic therapy (PDT). © 2021 Elsevier Ltd
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DOI
10.1016/j.dyepig.2021.109307
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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