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dc.contributor.author조영주-
dc.contributor.author김승정-
dc.contributor.author류동열-
dc.contributor.author김민혜-
dc.date.accessioned2021-03-02T16:30:43Z-
dc.date.available2021-03-02T16:30:43Z-
dc.date.issued2019-
dc.identifier.issn2213-2198-
dc.identifier.issn2213-2201-
dc.identifier.otherOAK-24662-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/257223-
dc.description.abstractBACKGROUND: Thus far, human leukocyte antigen (HLA)-B*58:01 has been recognized as the most important risk factor for allopurinol induced severe cutaneous adverse reactions (SCARs). OBJECTIVE: To determine the usefulness of prospective screening for the HLA-B*58:01 allele to identify Korean individuals at risk for SCARs induced by allopurinol treatment. METHODS: We prospectively enrolled 542 patients with chronic renal insufficiency (CRI) from 10 hospitals nationwide and performed DNA genotyping to determine whether they carried the HLA-B*58:01 allele. Of these, 503 HLA-B*58:01-negative patients (92.8% of total) were treated with allopurinol, and 39 HLA-B*58:01-positive patients (7.2%) were treated with febuxostat, an alternative drug. The patients then were followed up biweekly for 90 days using a telephone survey to monitor symptoms of adverse drug reactions, including SCARs. As a control, we used the historical incidence rate of allopurinol-induced SCARs in 4002 patients with CRI from the same hospitals who were enrolled retrospectively. RESULTS: Nineteen patients in the prospective cohort developed mild and transient adverse reactions but none showed allopurinol-induced SCARs. By contrast, we identified 38 patients with allopurinol-induced SCARs (0.95%) in the historical control. The difference in the incidence of allopurinol-induced SCARs between the prospective cohort and historical control was statistically significant (0% vs 0.95%, respectively; P = .029). CONCLUSIONS: The present study demonstrated the clinical usefulness of the HLA-B*58:01 screening test before allopurinol administration to prevent allopurinol-induced SCARs in patients with CRI. (C) 2018 American Academy of Allergy, Asthma & Immunology-
dc.languageEnglish-
dc.publisherELSEVIER-
dc.subjectAllopurinol-
dc.subjectHLA-B*58:01 allele-
dc.subjectDrug hypersensitivity-
dc.subjectRenal insufficiency-
dc.subjectChronic-
dc.titleEfficacy of the HLA-B*58:01 Screening Test in Preventing Allopurinol-Induced Severe Cutaneous Adverse Reactions in Patients with Chronic Renal Insufficiency-A Prospective Study-
dc.typeArticle-
dc.relation.issue4-
dc.relation.volume7-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage1271-
dc.relation.lastpage1276-
dc.relation.journaltitleJOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE-
dc.identifier.doi10.1016/j.jaip.2018.12.012-
dc.identifier.wosidWOS:000463732500024-
dc.identifier.scopusid2-s2.0-85059943172-
dc.author.googlePark, Heung-Woo-
dc.author.googleKim, Dong Ki-
dc.author.googleKim, Sae-Hoon-
dc.author.googleKim, Sejoong-
dc.author.googleChae, Dong-Wan-
dc.author.googleYang, Min-Suk-
dc.author.googleOh, Yun Kyu-
dc.author.googleLee, Jung Pyo-
dc.author.googleJung, Jae-Woo-
dc.author.googleShin, Jungho-
dc.author.googleHwang, Jin Ho-
dc.author.googleKang, Min-Gyu-
dc.author.googleKim, Sun Moon-
dc.author.googleKwon, Soon Kil-
dc.author.googleKim, Hye-Young-
dc.author.googleKim, Min-Hye-
dc.author.googleKim, Seung-Jung-
dc.author.googleRyu, Dong-Ryeol-
dc.author.googleCho, Young-Joo-
dc.author.googleJee, Young-Koo-
dc.author.googleKim, So Mi-
dc.author.googleLee, Eun Kyoung-
dc.author.googleKim, Ju-Young-
dc.author.googleCho, Hyun Seop-
dc.author.googleJeong, Yi Yeong-
dc.author.googleKim, Sang-Heon-
dc.author.googleJun, Jae-Bum-
dc.author.googlePark, Joon-Sung-
dc.author.googleKim, Gheun-Ho-
dc.author.googleKim, Sujeong-
dc.author.googleJung, Hee-Yeon-
dc.author.googleLee, Jong-Myung-
dc.contributor.scopusid조영주(55472202600)-
dc.contributor.scopusid김승정(8619054500)-
dc.contributor.scopusid류동열(7103144218)-
dc.contributor.scopusid김민혜(55572220900)-
dc.date.modifydate20210901081001-
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의과대학 > 의학과 > Journal papers
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