View : 753 Download: 53

Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation

Title
Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation
Authors
Park, Doo RiKim, JiheeKim, Gyeong MinLee, HaeseungKim, MinheeHwang, DonghyunLee, HanaKim, Han-SungKim, WankyuPark, Min ChanShim, HyunboLee, Soo Young
Ewha Authors
이수영심현보김완규박두리이해승
SCOPUS Author ID
이수영scopusscopus; 심현보scopus; 김완규scopus; 박두리scopusscopus
Issue Date
2020
Journal Title
NATURE COMMUNICATIONS
ISSN
2041-1723JCR Link
Citation
NATURE COMMUNICATIONS vol. 11, no. 1
Publisher
NATURE RESEARCH
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Osteoarthritis (OA), primarily characterized by articular cartilage destruction, is the most common form of age-related degenerative whole-joint disease. No disease-modifying treatments for OA are currently available. Although OA is primarily characterized by cartilage destruction, our understanding of the processes controlling OA progression is poor. Here, we report the association of OA with increased levels of osteoclast-associated receptor (OSCAR), an immunoglobulin-like collagen-recognition receptor. In mice, OSCAR deletion abrogates OA manifestations, such as articular cartilage destruction, subchondral bone sclerosis, and hyaline cartilage loss. These effects are a result of decreased chondrocyte apoptosis, which is caused by the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in induced OA. Treatments with human OSCAR-Fc fusion protein attenuates OA pathogenesis caused by experimental OA. Thus, this work highlights the function of OSCAR as a catabolic regulator of OA pathogenesis, indicating that OSCAR blockade is a potential therapy for OA.
DOI
10.1038/s41467-020-18208-y
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
Files in This Item:
s41467-020-18208-y.pdf(5.08 MB) Download
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

BROWSE