View : 113 Download: 0

Incidence, mortality, and cardiovascular diseases in pituitary adenoma in Korea: a nationwide population-based study

Title
Incidence, mortality, and cardiovascular diseases in pituitary adenoma in Korea: a nationwide population-based study
Authors
Oh, Jae SangKim, Hyun JungHann, Hoo JaeKang, Tae UkKim, Dong SookKang, Min JiLee, Ji YoungShim, Jai JoonLee, Man RyulAhn, Hyeong Sik
Ewha Authors
한후재
SCOPUS Author ID
한후재scopus
Issue Date
2021
Journal Title
PITUITARY
ISSN
1386-341XJCR Link

1573-7403JCR Link
Citation
PITUITARY vol. 24, no. 1, pp. 38 - 47
Keywords
Pituitary neoplasmIncidenceMortalityStrokeCardiovascular
Publisher
SPRINGER
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Purpose Few nationally representative studies have evaluated the epidemiology of PA (pituitary adenoma). This South Korean study evaluated the incidence of different PA subtypes, cardiovascular disease (CVD), and related mortality. Methods This population-based study evaluated 31,898 patients with PA during 2005-2015. The incidence of PA, mortality, and CVD occurrence in PA cases were evaluated during a median follow-up of 5.3 years (range: 0-10 years). Cox regression analysis was used to evaluate the associations between CVD and mortality. Results The annual incidences (per 100,000 population) were 3.5 for non-functioning pituitary adenoma (NFPA), 1.6 for prolactinoma (PRL), 0.5 for growth hormone-secreting pituitary adenoma (GH), and 0.2 for adrenocorticotropic or thyroid-stimulating hormone-secreting pituitary adenoma (ACTH + TSH). The standardized mortality ratios were 1.9 for ACTH + TSH, 1.7 for NFPA with hypopituitarism, 1.4 for NFPA without hypopituitarism, 1.3 for GH, and 1.1 for PRL. During 2005-2015, the overall incidence of CVD among PA patients was 6.6% (2106 cases), and the standardized incidence ratios were 4.1 for hemorrhagic stroke, 3.0 for ischemic stroke, and 1.7 for acute myocardial infarction. The standardized incidence ratios for stroke were significantly higher in the ACTH + TSH and NFPA groups, which also had higher risks of CVD-related mortality, relative to the PRL and GH groups. Conclusion South Korea had a relatively high incidence of NFPA. The incidence of stroke was highest for ACTH + TSH and NFPA, which was directly related to mortality during long-term follow-up. Patients with these types of PA should receive stroke prevention measures to reduce their risk of mortality.
Show the fulltext
DOI
10.1007/s11102-020-01084-6
Appears in Collections:
의과대학 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE