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Napthalimide-based fluorescent probe for selective and sensitive sensing of formaldehyde and biological applications
- Title
- Napthalimide-based fluorescent probe for selective and sensitive sensing of formaldehyde and biological applications
- Authors
- Nasirian A.; Tikum A.F.; Fortibui M.M.; Lee S.; Kim J.
- Ewha Authors
- 김진흥
- SCOPUS Author ID
- 김진흥
- Issue Date
- 2021
- Journal Title
- Dyes and Pigments
- ISSN
- 0143-7208
- Citation
- Dyes and Pigments vol. 188
- Keywords
- Condensation reaction; Formaldehyde sensing; Luminescent detection; Napthalimide; Two-photon excitation
- Publisher
- Elsevier Ltd
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Formaldehyde (FA) is a colorless, flammable, foul-smelling chemical used in building materials and in the production of numerous household chemical products. To develop a fluorescent chemosensor for FA, a newly prepared probe 1 containing napthalimide as a fluorophore and hydrazine as a binding site of FA was designed and prepared. The amine group of the hydrazine reacts with FA to form an imide bond. Indeed, the absorption band of probe 1 at 438 nm shifted to 443 nm upon the addition of FA, indicating that the condensation reaction occurred. Also, the addition of FA to probe 1 induced a large enhancement of the emission band at 532 nm compared with the relatively very weak fluorescent emission of probe 1 alone. This high specificity toward FA was observed over other competing analytes such as Ca2+, Mg2+, acetaldehyde, benzaldehyde, salicylaldehyde, glucose, glutathione, Na2S, NaHS, H2O2, and tert-butylhydroperoxy radical. The typical two-photon dye present in probe 1 also afforded intense fluorescence upon excitation, even at 800 nm, demonstrating that probe 1 could be used for a two-photon fluorescent probe for FA sensing. Probe 1 had a quick response time in the sensing of FA at room temperature. In addition, breast cancer cells treated with probe 1 exhibited intense fluorescence imaging upon exposure to FA, indicating that probe 1 could be used for monitoring FA in living cells. This probe can lead to new possibilities for unique interactions with biological molecules for applications. © 2021
- DOI
- 10.1016/j.dyepig.2021.109156
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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