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Pharmacotherapy against Oxidative Stress in Chronic Kidney Disease: Promising Small Molecule Natural Products Targeting Nrf2-HO-1 Signaling

Title
Pharmacotherapy against Oxidative Stress in Chronic Kidney Disease: Promising Small Molecule Natural Products Targeting Nrf2-HO-1 Signaling
Authors
Uddin, Md JamalKim, Ee HyunHannan, Md. AbdulHa, Hunjoo
Ewha Authors
하헌주Md Jamal Uddin
SCOPUS Author ID
하헌주scopus; Md Jamal Uddinscopus
Issue Date
2021
Journal Title
ANTIOXIDANTS
ISSN
2076-3921JCR Link
Citation
ANTIOXIDANTS vol. 10, no. 2
Keywords
chronic kidney diseasesoxidative stressNrf2HO-1small molecule natural products
Publisher
MDPI
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Review
Abstract
The global burden of chronic kidney disease (CKD) intertwined with cardiovascular disease has become a major health problem. Oxidative stress (OS) plays an important role in the pathophysiology of CKD. The nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant responsive element (ARE) antioxidant system plays a critical role in kidney protection by regulating antioxidants during OS. Heme oxygenase-1 (HO-1), one of the targets of Nrf2-ARE, plays an important role in regulating OS and is protective in a variety of human and animal models of kidney disease. Thus, activation of Nrf2-HO-1 signaling may offer a potential approach to the design of novel therapeutic agents for kidney diseases. In this review, we have discussed the association between OS and the pathogenesis of CKD. We propose Nrf2-HO-1 signaling-mediated cell survival systems be explored as pharmacological targets for the treatment of CKD and have reviewed the literature on the beneficial effects of small molecule natural products that may provide protection against CKD.
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DOI
10.3390/antiox10020258
Appears in Collections:
약학대학 > 약학과 > Journal papers
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