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Digital breast tomosynthesis as a breast cancer screening tool for women with gynecologic cancer

Title
Digital breast tomosynthesis as a breast cancer screening tool for women with gynecologic cancer
Authors
Kim D.-h.Chung J.Cha E.-S.Lee J.E.Kim J.H.
Ewha Authors
차은숙이지은정진김정현
SCOPUS Author ID
차은숙scopus; 이지은scopus; 정진scopus; 김정현scopus
Issue Date
2020
Journal Title
Journal of the Korean Society of Radiology
ISSN
1738-2637JCR Link
Citation
Journal of the Korean Society of Radiology vol. 81, no. 4, pp. 886 - 898
Keywords
BreastBreast NeoplasmsDigital Breast TomosynthesisGynecologyMass Screening
Publisher
Korean Radiological Society
Indexed
SCOPUS; KCI scopus
Document Type
Article
Abstract
Purpose The purpose of our study was to evaluate digital breast tomosynthesis as a breast cancer screening modality for women with gynecologic cancer. Materials and Methods This retrospective study included patients with underlying gynecologic malignancies who underwent screening digital breast tomosynthesis for breast cancer. The cancer detection rate, recall rate, sensitivity, specificity, and positive predictive value (PPV) were calculated. PPV1 was defined as the percentage of all positive screening exams that have a tissue diagnosis of cancer within a year. PPV2 was defined as the percentage of all diagnostic exams (and Breast Imaging Reporting and Data System category 4, 5 from screening setting) with a recommendation for tissue diagnosis that have cancer within a year. PPV3 was defined as the percentage of all known biopsies actually performed that resulted in a tissue diagnosis of cancer within the year. For each case of screen-detected cancer, we analyzed the age, type of underlying gynecologic malignancy, breast density, imaging features, final Breast Imaging Reporting and Data System assessment, histologic type, T and N stages, molecular subtype, and Ki-67 index. Results Among 508 patients, 7 with breast cancer were identified after a positive result. The cancer detection rate was 13.8 per 1000 screening exams, and the recall rate was 17.9%. The sensitivity was 100%, and the specificity was 83.2%. The false negative rate was 0 per 1000 exams. The PPV1, PPV2, and PPV3 were 7.7, 31.8, and 31.8, respectively. Conclusion Digital breast tomosynthesis may be a promising breast cancer screening modality for women with gynecologic cancer, based on the high cancer detection rate, high sensitivity, high PPV, and high detection rate of early-stage cancer observed in our study. © 2020 The Korean Society of Radiology.
DOI
10.3348/jksr.2020.81.4.886
Appears in Collections:
의과대학 > 의학과 > Journal papers
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