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Comparable Plasma Lipid Changes in Patients with High-Grade Cervical Intraepithelial Neoplasia and Patients with Cervical Cancer

Title
Comparable Plasma Lipid Changes in Patients with High-Grade Cervical Intraepithelial Neoplasia and Patients with Cervical Cancer
Authors
Nam, MisoSeo, Sang-SooJung, SunheeJang, Seo YoungLee, JueunKwon, MinjiKhan, ImranRyu, Do HyunKim, Mi KyungHwang, Geum-Sook
Ewha Authors
황금숙
SCOPUS Author ID
황금숙scopusscopus
Issue Date
2021
Journal Title
JOURNAL OF PROTEOME RESEARCH
ISSN
1535-3893JCR Link

1535-3907JCR Link
Citation
JOURNAL OF PROTEOME RESEARCH vol. 20, no. 1, pp. 740 - 750
Keywords
global lipid profilinglipid metabolismcervical cancercervical intraepithelial neoplasialiquid chromatography-mass spectrometry
Publisher
AMER CHEMICAL SOC
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
Cervical cancer is the fourth most prevalent cancer among women worldwide and usually develops from cervical intraepithelial neoplasia (CIN). In the present study, we compared alterations in lipids associated with high-grade CIN and cervical cancer with those associated with a normal status and low-grade CIN by performing global lipid profiling on plasma (66 healthy controls and 55 patients with CIN1, 44 with CIN2/3, and 60 with cervical cancer) using ultraperformance liquid chromatography/quadrupole time-of-flight mass spectrometry. We identified 246 lipids and found 31 lipids with similar alterations in both high-grade CIN and cervical cancer. Among these 31 lipids, four lipid classes (phosphatidylcholine, phosphatidylethanolamine, diglyceride, and free fatty acids) were identified as the major lipid classes with significant differences in the patients with CIN2/3 and cervical cancer compared to the healthy controls and the patients with CIN1. Lipid metabolites belonging to the same classes were positively correlated with each other. High-grade CIN and cervical cancer induce comparable changes in lipid levels, which are closely related to the development of cervical tumors. These results suggest that lipid profiling is a useful method for monitoring progression to cervical cancer.
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DOI
10.1021/acs.jproteome.0c00640
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자연과학대학 > 화학·나노과학전공 > Journal papers
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