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Safety and Optimal Timing of BCG Vaccination in Infants Born to Mothers Receiving Anti-TNF Therapy for Inflammatory Bowel Disease
- Title
- Safety and Optimal Timing of BCG Vaccination in Infants Born to Mothers Receiving Anti-TNF Therapy for Inflammatory Bowel Disease
- Authors
- Park, Sang Hyoung; Kim, Hyo Jong; Lee, Chang Kyun; Song, Eun Mi; Kang, Sang-Bum; Jang, Byung Ik; Kim, Eun Soo; Kim, Kyeong Ok; Lee, Yoo Jin; Kim, Eun Young; Jung, Yun Jin; Park, Soo-Kyung; Il Park, Dong; Ye, Byong Duk; Jung, Sung-Ae; Yang, Suk-Kyun
- Ewha Authors
- 정성애; 송은미
- SCOPUS Author ID
- 정성애; 송은미
- Issue Date
- 2020
- Journal Title
- JOURNAL OF CROHNS & COLITIS
- ISSN
- 1873-9946
1876-4479
- Citation
- JOURNAL OF CROHNS & COLITIS vol. 14, no. 12, pp. 1780 - 1784
- Keywords
- Inflammatory bowel disease; anti-tumor necrosis factor; BCG; infant
- Publisher
- OXFORD UNIV PRESS
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Backgrounds and Aims: We aimed to evaluate the safety of Bacille Calmette-Guerin [BCG] vaccination in infants born to mothers receiving anti-tumour necrosis factor [anti-TNF] therapy for inflammatory bowel disease. Methods: Adverse events of BCG vaccination were evaluated in 90 infants who were last exposed to anti-TNF agents at a median of gestational week 30. Results: After receiving BCG vaccination at a median age of 6 months [range, 0.25-11 months], three infants [3.3%] showed injection site swelling, two of whom also showed axillar lymphadenopathy. The rates of adverse events were similar between infants who were last exposed to anti-TNF agents before the third trimester [n = 35] and those who were last exposed in the third trimester [n = 55] [2.9% vs 3.6%; p = 1.00]. All adverse events were spontaneously resolved and there were no serious adverse events such as active tuberculosis infection or death. Conclusions: BCG vaccination after 6 months of age is of low risk in infants exposed to anti-TNF agents in utero.
- DOI
- 10.1093/ecco-jcc/jjaa099
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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