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Acremonidin E produced by Penicillium sp. SNF123, a fungal endophyte of Panax ginseng, has antimelanogenic activities
- Title
- Acremonidin E produced by Penicillium sp. SNF123, a fungal endophyte of Panax ginseng, has antimelanogenic activities
- Authors
- Kim, Kyuri; Jeong, Hae-In; Yang, Inho; Nam, Sang-Jip; Lim, Kyung-Min
- Ewha Authors
- 임경민; 남상집
- SCOPUS Author ID
- 임경민; 남상집
- Issue Date
- 2021
- Journal Title
- JOURNAL OF GINSENG RESEARCH
- ISSN
- 1226-8453
2093-4947
- Citation
- JOURNAL OF GINSENG RESEARCH vol. 45, no. 1, pp. 98 - 107
- Keywords
- Acremonidin E; Endophytic fungus; Melanogenesis; Panax ginseng; Penicillium sp. SNF12
- Publisher
- KOREAN SOC GINSENG
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Article
- Abstract
- Background: Ginseng extracts and ginseng-fermented products are widely used as functional cosmetic ingredients for their whitening and antiwrinkle effects. Recently, increasing attention has been given to bioactive metabolites isolated from endophytic fungi. However, little is known about the bioactive metabolites of the fungi associated with Panax ginseng Meyer. Methods: An endophytic fungus, Penicillium sp. SNF123 was isolated from the root of P. ginseng, from which acremonidin E was purified. Acremonidin E was tested on melanin synthesis in the murine melanoma cell line B16F10, in the human melanoma cell line MNT-1, and in a pigmented 3D-human skin model, Melanoderm. Results: Acremonidin E reduced melanogenesis in alpha-melanocyte-stimulating hormone (alpha-MSH)-stimulated B16F10 cells with minimal cytotoxicity. qRT-PCR analysis demonstrated that acremonidin E downregulated melanogenic genes, including tyrosinase and tyrosinase-related protein 1 (TRP-1), while their enzymatic activities were unaffected. The antimelanogenic effects of acremonidin E were further confirmed in MNT-1 and a pigmented 3D human epidermal skin model, Melanoderm. Immunohistological examination of the Melanoderm further confirmed the regression of both melanin synthesis and melanocyte activation in the treated tissue. Conclusion: This study demonstrates that acremonidin E, a bioactive metabolite derived from a fungal endophyte of P. ginseng, can inhibit melanin synthesis by downregulating tyrosinase, illuminating the potential utility of microorganisms associated with P. ginseng for cosmetic ingredients. (C) 2019 The Korean Society of Ginseng, Published by Elsevier Korea LLC.
- DOI
- 10.1016/j.jgr.2019.11.007
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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